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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
EBOV/MARV-IN-1
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| Category | Filovirus |
| CAS | 2479465-67-1 |
| Description | EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) with EC50s of 0.31 and 0.82 µM, respectively. It has broad-spectrum activity and low cytotoxicity (SI>100) in HeLa cells. |
Product Information
| Synonyms | VUN65671; VUN-65671; VUN 65671; N-[4-(4-Methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)benzamide; Benzamide, N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)- |
| IUPAC Name | N-[4-(4-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl]-4-(morpholin-4-ylmethyl)benzamide |
| Molecular Weight | 461.52 |
| Molecular Formula | C25H30F3N3O2 |
| Canonical SMILES | CC1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=C(C=C3)CN4CCOCC4)C(F)(F)F |
| InChI | InChI=1S/C25H30F3N3O2/c1-18-8-10-31(11-9-18)23-7-6-21(16-22(23)25(26,27)28)29-24(32)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-7,16,18H,8-15,17H2,1H3,(H,29,32) |
| InChIKey | VVJSZYWIEBDKTC-UHFFFAOYSA-N |
| Boiling Point | 505.0±50.0°C at 760 mmHg |
| Purity | ≥95% |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | Solid Powder |
| Storage | Store at -20°C |
| In Vitro | EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088). |
| Target | Filovirus |
