EBOV/MARV-IN-1

Category	Filovirus
CAS	2479465-67-1
Description	EBOV/MARV-IN-1 is a potent inhibitor of Ebola virus (EBOV) and Marburg virus (MARV) with EC50s of 0.31 and 0.82 µM, respectively. It has broad-spectrum activity and low cytotoxicity (SI>100) in HeLa cells.

Quotation Now

Synonyms	VUN65671; VUN-65671; VUN 65671; N-[4-(4-Methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)benzamide; Benzamide, N-[4-(4-methyl-1-piperidinyl)-3-(trifluoromethyl)phenyl]-4-(4-morpholinylmethyl)-
IUPAC Name	N-[4-(4-methylpiperidin-1-yl)-3-(trifluoromethyl)phenyl]-4-(morpholin-4-ylmethyl)benzamide
Molecular Weight	461.52
Molecular Formula	C25H30F3N3O2
Canonical SMILES	CC1CCN(CC1)C2=C(C=C(C=C2)NC(=O)C3=CC=C(C=C3)CN4CCOCC4)C(F)(F)F
InChI	InChI=1S/C25H30F3N3O2/c1-18-8-10-31(11-9-18)23-7-6-21(16-22(23)25(26,27)28)29-24(32)20-4-2-19(3-5-20)17-30-12-14-33-15-13-30/h2-7,16,18H,8-15,17H2,1H3,(H,29,32)
InChIKey	VVJSZYWIEBDKTC-UHFFFAOYSA-N
Boiling Point	505.0±50.0°C at 760 mmHg
Purity	≥95%
Density	1.2±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid Powder
Storage	Store at -20°C
In Vitro	EBOV/MARV-IN-1 (12.5 µM; 48 h) inhibits HIV/EBOV-GP (EC50=12 nM) and HIV/MARV-GP (EC50=180 nM) pseudotype virus in A549 cells containing a luciferase reporter gene, with low cytotoxicity (SI =2088).
Target	Filovirus