(E)-3,4-Dimethoxycinnamic acid

Category	Virus Protease
CAS	14737-89-4
Description	(E)-3,4-Dimethoxycinnamic acid is the less active isomer of 3,4-Dimethoxycinnamic acid, which has anti-apoptotic effects on L-02 cells via the ROS-mediated signaling pathway.

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Product Information

Synonyms	(E)-O-Methylferulic acid; (E)-3-(3,4-dimethoxyphenyl)acrylic acid; (2E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid; trans-3,4-Dimethoxycinnamic acid; (E)-3',4'-Dimethoxycinnamic acid; 2-Propenoic acid, 3-(3,4-dimethoxyphenyl)-, (2E)-
IUPAC Name	(E)-3-(3,4-dimethoxyphenyl)prop-2-enoic acid
Molecular Weight	208.21
Molecular Formula	C11H12O4
Canonical SMILES	COC1=C(C=C(C=C1)C=CC(=O)O)OC
InChI	InChI=1S/C11H12O4/c1-14-9-5-3-8(4-6-11(12)13)7-10(9)15-2/h3-7H,1-2H3,(H,12,13)/b6-4+
InChIKey	HJBWJAPEBGSQPR-GQCTYLIASA-N
Boiling Point	367.4±27.0°C (Predicted)
Melting Point	181-183°C
Flash Point	140.6±20.0 °C
Purity	≥98%
Density	1.203±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	White to off-white (Solid)
Storage	Store at RT
Complexity	237
Exact Mass	208.07355886
Index Of Refraction	1.562
In Vitro	3,4-Dimethoxycinnamic acid (Methyl ferulic acid; 25, 50 and 100 µM) attenuates the ethanol-induced Apoptosis of ethanolexposed L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) inhibits the expression levels of Nox4 and p22phox in L-02 cells. 3,4-Dimethoxycinnamic acid (25, 50 and 100 µM) treatment attenuates ethanol-induced MAPK phosphorylation in L-02 cells. 3,4-Dimethoxycinnamic acid decreases the expression levels of superoxide dismutase, catalase and phospholipid hydroperoxide gluthione peroxidase, and downregulates the levels of Bax/Bcl-2 and the cleaved forms of Caspase-3 in a dose- and time-dependent manner.
PSA	64.99000
Target	Reactive Oxygen Species; Virus Protease
Vapor Pressure	0.0±0.9 mmHg at 25°C

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