Dynasore

Category	Herpes simplex Virus (HSV)
CAS	304448-55-3
Description	Dynasore is a cell-permeable and noncompetitive inhibitor of the GTPase activity of dynamin with IC50 value of 15 µM.

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Product Information

Synonyms	Dynasore
Molecular Weight	322.31
Molecular Formula	C18H14N2O4
Canonical SMILES	C1=CC=C2C=C(C(=CC2=C1)C(=O)NNC=C3C=CC(=O)C(=C3)O)O
InChI	InChI=1S/C18H14N2O4/c21-15-6-5-11(7-17(15)23)10-19-20-18(24)14-8-12-3-1-2-4-13(12)9-16(14)22/h1-10,19,22-23H,(H,20,24)/b11-10+
InChIKey	NRQJUIHYFNUXFT-ZHACJKMWSA-N
Purity	>98%
Density	1.36±0.1 g/cm3
Solubility	In Vitro: DMSO : ≥ 50 mg/mL(155.13 mM) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (7.76 mM); Clear solution
Appearance	Light brown to brown (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	470
Exact Mass	322.09535693
Index Of Refraction	1.665
In Vitro	Dynasore interferes with the GTPase activity of dynamin1, dynamin2, and Drp1, the mitochondrial dynamin, but not of other small GTPases. Dynasore acts as a potent inhibitor of endocytic pathways known to depend on dynamin by rapidly blocking coated vesicle formation within seconds of dynasore addition. Two types of coated pit intermediates accumulate during dynasore treatment, g-shaped, half formed pits and O-shaped, fully formed pits, captured while pinching off. Dynasore inhibits HSV-1 and HSV-2 infection of human epithelial and neuronal cells, including primary genital tract cells and human fetal neurons and astrocytes. Dynasore reduces the number of viral capsids reaching the nuclear pore if added at the time of viral entry and that, when added as late as 8 h postentry, dynasore blocks the transport of newly synthesized viral proteins from the nucleus to the cytosol. Dynasore prevents ischemia/reperfusion induced elevation of left ventricular end diastolic pressure. Dynasore also decreases cardiac troponin I efflux during reperfusion and reduces infarct size. In cultured adult mouse cardiomyocytes subjected to oxidative stress, dynasore increases cardiomyocyte survival and viability.
In Vivo	Dynasore ameliorates the motor dysfunction greatly at 3, 7, and 10 days after SCI in rats. Dynasore significantly enhances motor function which may be by inhibiting the activation of neuronal mitochondrial apoptotic pathway and astrocytic proliferation in rats after SCI.
PSA	102.15000
Target	IC50: 15 μM (GTPase activity of dynamin1 and 2)
XLogP3-AA	3.6