Diiodohydroxyquinoline

Category	SARS-CoV
CAS	83-73-8
Description	5,7-Diiodo-8-Quinolinol is a topical therapeutic agent with satisfactory antibacterial properties. It is poorly absorbed from the gastrointestinal tract and is used as a luminal amebicide. It acts by chelation of ferrous ions essential for metabolism. It is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis. It was discovered by Adco Co.

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Synonyms	iodoquinol;83-73-8;Diiodohydroxyquinoline;5,7-diiodoquinolin-8-ol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol;Diiodoquin;Diodoquin;Yodoxin;DIIODOHYDROXYQUIN;Lanodoxin;Searlequin;Zoaquin;Ioquin;Quinadome;Sebaquin;8-Quinolinol, 5,7-diiodo-;Diodohydroxyquin;Dijodoxichinoline;Enterodiamoebin;Diamoebin;Dinoleine;Diodoquine;Diodoxylin;Direxiode;Disoquin;Embequin;Enterosept;Floraquin;Fluoraquin;Moebiquin;Dyodin;Di-quinol;Stanquinate;Rafamebin;5,7-Diiodo-oxine;Ioquin suspension;Dijodoxichinolinum;8-Hydroxy-5,7-diiodoquinoline;5,7-Diodo-8-quinolinol;Diodoxyquinoleine;Diiodoidrossichinolina;Panaquin;Diiodohidroxiquinoleina;Diiodohydroxyquinoleine;Diiodohydroxyquinolinum;SS 578;Enterodiamoebine;NSC 8704;NSC-8704;5,7-Diiod-8-chinolinol [IUPAC];Diiodohydroxyquinoline [INN];MLS000069404;CHEBI:5950;DTXSID6023155;63W7IE88K8;MMV002817;SS-578;NCGC00018098-04;SMR000059090;C9H5I2NO;Diiodohydroxyquinoline (INN);Iodoquinol [USAN];DTXCID003155;Caswell No. 354;Iodoquinol;5,7-Diiodo-8-hydroxyquinoline;5,7-Diiodo-8-quinolinol;CAS-83-73-8;Diiodoidrossichinolina [DCIT];HSDB 3224;SR-01000002969;Diiodohydroxyquinolinum [INN-Latin];Iodoquinol [USAN:USP];Diiodohydroxyquinoleine [INN-French];EINECS 201-497-9;5,7-Diiod-8-chinolinol;Diiodohidroxiquinoleina [INN-Spanish];EPA Pesticide Chemical Code 024003;BRN 0153639;Searlewuin;Meobiquin;UNII-63W7IE88K8;AI3-16443;5,7-Diiodooxine;component of Vytone;Iodoquinol (USP);Yodoxin (TN);MFCD00006789;Spectrum_000943;IODOQUINOL [MI];8-Quinolinol,7-diiodo-;Spectrum2_001041;Spectrum3_000470;Spectrum4_000020;Spectrum5_000872;IODOQUINOL [HSDB];4,7-Diiodo-8-quinolinol;bmse000836;EC 201-497-9;cid_3728;SCHEMBL3460;IODOQUINOL [USP-RS];BSPBio_002180;CBDivE_011080;KBioGR_000399;KBioSS_001423;ksc-8-193;CHEMBL86754;DivK1c_000119;SPECTRUM1500353;SPBio_000962;DI-IODOHYDROXY QUINOLINE;5,7-bis(iodanyl)quinolin-8-ol;BDBM66035;HMS500F21;KBio1_000119;KBio2_001423;KBio2_003991;KBio2_006559;KBio3_001400;UXZFQZANDVDGMM-UHFFFAOYSA-;IODOQUINOL [USP IMPURITY];NSC8704;NINDS_000119;WLN: T66 BNJ GI II JQ;HMS1920H05;HMS2091N15;HMS2230G24;HMS3369C20;IODOQUINOL [USP MONOGRAPH];KUC105860N;Pharmakon1600-01500353;HY-B1400;Tox21_110823;CCG-40132;NSC757077;s4565;STK070581;DIIODOHYDROXYQUINOLINE [MART.];AKOS000120804;Tox21_110823_1;5,7-Diiodo-8-hydroxyquinoline, 97%;CS-4910;DB09115;DIIODOHYDROXYQUINOLINE [WHO-DD];Iodoquinol (5,7-Diiodoquinolin-8-ol);NSC-757077;IDI1_000119;NCGC00018098-01;NCGC00018098-02;NCGC00018098-03;NCGC00018098-05;NCGC00018098-07;NCGC00018098-08;NCGC00021685-03;NCGC00021685-04;DS-17759;SBI-0051417.P003;DB-056739;AM20061527;D1736;NS00003663;EN300-18288;C07636;D00581;F12461;AB00052024_12;AN-329/13210059;Q5276473;SR-01000002969-2;SR-01000002969-5;BRD-K75855670-001-06-8;BRD-K75855670-001-14-2;Z57825347;F3034-0058;Iodoquinol, United States Pharmacopeia (USP) Reference Standard;InChI=1/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H;
IUPAC Name	5,7-diiodoquinolin-8-ol
Molecular Weight	530.5
Molecular Formula	C26H26O12
Canonical SMILES	COC(=O)[C@@]1(C[C@H]([C@H]([C@@H](C1)OC(=O)/C=C/C2=CC(=C(C=C2)O)O)OC(=O)/C=C/C3=CC(=C(C=C3)O)O)O)O
InChI	InChI=1S/C9H5I2NO/c10-6-4-7(11)9(13)8-5(6)2-1-3-12-8/h1-4,13H
InChIKey	UXZFQZANDVDGMM-UHFFFAOYSA-N
Boiling Point	401.8±45.0 °C \| Condition: Press: 760 Torr
Melting Point	210 °C
Purity	98 %
Density	2.491±0.06 g/cm³ \| Condition: Temp: 20 °C Press: 760 Torr
Solubility	10 mM in DMSO
Appearance	Yellow to tan powder or crystals
Application	5,7-Diiodo-8-Quinolinol is active against both cyst and trophozoites that are localized in the lumen of the intestine. It is used in the treatment of amoebiasis. It is considered the drug of choice for treating asymptomatic or moderate forms of amebiasis.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	191
Exact Mass	396.84606