Didanosine-d2

Category	Human immunodeficiency Virus (HIV)
Description	Didanosine-d2 is the deuterium labeled Didanosine. Didanosine (Videx) is a reverse transcriptase inhibitor with an IC50 of 0.49 μM.

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Synonyms	Didanosine-d2\|HY-B0249S\|CS-0311669
Molecular Weight	238.24
Molecular Formula	C10H12N4O3
Canonical SMILES	C1CC(OC1CO)N2C=NC3=C2N=CNC3=O
Purity	≥98% (HPLC)
Solubility	DMSO: soluble, Methanol: soluble, Water: soluble
Appearance	Solid powder
Storage	Store at -20°C
Complexity	348
Exact Mass	238.10349375
In Vitro	Didanosine-d2 is intended for use as an internal standard for the quantification of didanosine by GC- or LC-MS. Didanosine is an antiviral nucleoside analog and an inhibitor of reverse transcriptase.1 It undergoes cellular amination and phosphorylation to its active triphosphate form, 2',3'-dideoxyadenosine 5'-triphosphate . Didanosine inhibits human T cell leukemia virus type 1 (HTLV-1) reverse transcriptase activity (IC50 = 30 nM).2 It inhibits the replication of HIV-1 clinical isolates containing various mutations in the gene encoding reverse transcriptase, pol, in isolated human peripheral blood mononuclear cells (PBMCs; IC50s = 0.3-11.1 μM).
In Vivo	Didanosine inhibits proliferation and differentiation of primary human skeletal muscle cells (IC50s = 1 and 0.1 mM, respectively), as well as decreases the activities of mitochondrial complex IV, also known as cytochrome c oxidase, and mitochondrial complex II, also known as succinate dehydrogenase, in the same cells when used at a concentration of 1 mM.4 In vivo, didanosine protects mice from HIV infection (EC50 = 13.7 mg/kg).
Target	HIV; Reverse Transcriptase
XLogP3-AA	-1.2