Diclofenac EP Impurity E

Category	Human immunodeficiency Virus (HIV)
CAS	59-48-3
Description	Diclofenac EP Impurity E is an impurity of Diclofenac, which is a non-selective COX inhibitor used as a non-steroidal anti-inflammatory drug (NSAID).

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Product Information

Synonyms	Diclofenac sodium EP impurity E; Diclofenac potassium EP impurity E; 1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 1,3-dihydro-; 1,3-Dihydro-2H-indol-2-one; 2-Indolinone; Oxindole; 2,3-Dihydro-1H-indol-2-one; 2-Indolone; 2-Oxindole; 2-Oxo-2,3-dihydroindole; 2-Oxoindole; 2-Oxoindoline; Indol-2(3H)-one; Indoline-2-one; NSC 274863; Oxindol
IUPAC Name	1,3-dihydroindol-2-one
Molecular Weight	133.15
Molecular Formula	C8H7NO
Canonical SMILES	C1C2=CC=CC=C2NC1=O
InChI	InChI=1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)
InChIKey	JYGFTBXVXVMTGB-UHFFFAOYSA-N
Boiling Point	227°C
Melting Point	128°C
Flash Point	190.0±18.0 °C
Purity	≥95%
Density	1.198±0.06 g/cm3
Solubility	Soluble in Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
Appearance	Light Brown to Brown Solid
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Complexity	155
Exact Mass	133.052763847
Index Of Refraction	1.640
In Vitro	Oxindole (Indolin-2-one) is a bicyclic structure consisting of a benzene ring fused to 2-pyrrolidone. Substituted indolinones can be referred as 'privileged structures' owing to their excellent binding affinity for many receptors and to the number of approved drugs containing this scaffold. Oxindole has been found in tissues and fluids of mammals as well as natural products produced by a range of plants, bacteria and invertebrates. 2-indolinone derivatives possess diverse range of pharmacological activities including anti-cancer, anti-HIV, anti-diabetic, antibacterial, antioxidant, kinase inhibitory, AChE inhibitory, anti-leishmanial, b3 adrenergic receptor agonistic, phosphatase inhibitory, analgesic, spermicidal, vasopressin antagonists, progesterone antagonists, neuroprotection, NMDA blocker and sleep inducing activities.
PSA	29.10000
Target	HIV
Vapor Pressure	0.0±0.7 mmHg at 25°C
XLogP3-AA	1.2