Dexamethasone-d4

Category	SARS-CoV
CAS	2305607-27-4
Description	Dexamethasone-d4 is deuterium labeled Dexamethasone. Dexamethasone (Hexadecadrol) is a glucocorticoid receptor agonist. Dexamethasone also significantly decreases CD11b, CD18, and CD62L expression on neutrophils, and CD11b and CD18 expression on monocytes. Dexamethasone is highly effective in the control of COVID-19 infection. Dexamethasone inhibits production of exosomes containing inflammatory microRNA-155 in lipopolysaccharide-induced macrophage inflammatory responses.

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Synonyms	dexamethasone-d4\|HY-14648S2\|CS-0377248\|9-fluoro-11beta,17,21-trihydroxy-16alpha-methyl-pregna-1,4-diene-3,20-dione-4,6,21,21-d4
Molecular Weight	396.49
Molecular Formula	C22H29FO5
Canonical SMILES	CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(CC2(C1(C(=O)CO)O)C)O)F)C
Purity	≥99% deuterated forms (d1-d4)
Solubility	DMF: 25 mg/ml DMSO: 30 mg/ml Ethanol: 3 mg/ml
Appearance	A solid
Storage	Store at -20°C
Complexity	805
Exact Mass	396.22500917
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
Target	Glucocorticoid Receptor; SARS-CoV; Autophagy; Complement System; Mitophagy;
XLogP3-AA	1.9