Decanoyl-RVKR-CMK

Category	Human immunodeficiency Virus (HIV)
CAS	150113-99-8
Description	Decanoyl-RVKR-CMK is a proprotein convertase inhibitor and has been found to restrain regulated secretion of the neuronal polypeptide VGF in PC12 cells.

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Synonyms	Decanoyl-Arg-Val-Lys-Arg-CMK; N2-(1-Oxodecyl)-L-arginyl-L-valyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-lysinamide
IUPAC Name	N-[(2S)-1-[[(2S)-1-[[(2S)-6-amino-1-[[(3S)-1-chloro-6-(diaminomethylideneamino)-2-oxohexan-3-yl]amino]-1-oxohexan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]decanamide
Molecular Weight	744.42
Molecular Formula	C34H66ClN11O5
Canonical SMILES	CCCCCCCCCC(=O)NC(CCCN=C(N)N)C(=O)NC(C(C)C)C(=O)NC(CCCCN)C(=O)NC(CCCN=C(N)N)C(=O)CCl
InChI	InChI=1S/C34H66ClN11O5/c1-4-5-6-7-8-9-10-18-28(48)43-25(17-14-21-42-34(39)40)31(50)46-29(23(2)3)32(51)45-26(15-11-12-19-36)30(49)44-24(27(47)22-35)16-13-20-41-33(37)38/h23-26,29H,4-22,36H2,1-3H3,(H,43,48)(H,44,49)(H,45,51)(H,46,50)(H4,37,38,41)(H4,39,40,42)/t24-,25-,26-,29-/m0/s1
InChIKey	NHBJTTGFHCHQHS-VZTVMPNDSA-N
Purity	>98%
Density	1.27±0.1 g/cm3(Predicted)
Solubility	Soluble in H2O
Appearance	Crystalline Solid
Storage	Store at -20°C
Complexity	1100
Exact Mass	743.4936919
Index Of Refraction	1.585
In Vitro	Decanoyl-RVKR-CMK (DecRVKRcmk) inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell. Decanoyl-RVKR-CMK (DecRVKRcmk) blocks regulated secretion of VGF. Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
PSA	283.29000
Target	HIV
XLogP3-AA	2