-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
ddATP-trisodium
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 72029-21-1 |
| Description | ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection. |
Product Information
| Molecular Weight | 541.13 |
| Molecular Formula | C10H13N5Na3O11P3 |
| Purity | ≥98% (HPLC) |
| Solubility | In Vitro: H2O : 125 mg/mL(231.00 mM;Need ultrasonic) |
| Appearance | Solid powder |
| Storage | -20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen) |
| In Vitro | ddATP (0.05-50 μM, 30 min) trisodium inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells. ddATP (100 μM, 5 h) trisodium reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes. ddATP trisodium inhibits HIV replication by inhibiting HIV reverse transcriptase. Result: Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. |
| Target | DNA/RNA Synthesis; HIV |
