ddATP-trisodium

Category	Human immunodeficiency Virus (HIV)
CAS	72029-21-1
Description	ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.

Quotation Now

Molecular Weight	541.13
Molecular Formula	C10H13N5Na3O11P3
Purity	≥98% (HPLC)
Solubility	In Vitro: H2O : 125 mg/mL(231.00 mM;Need ultrasonic)
Appearance	Solid powder
Storage	-20°C, protect from light, stored under nitrogen *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
In Vitro	ddATP (0.05-50 μM, 30 min) trisodium inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells. ddATP (100 μM, 5 h) trisodium reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes. ddATP trisodium inhibits HIV replication by inhibiting HIV reverse transcriptase. Result: Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates.
Target	DNA/RNA Synthesis; HIV