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Antiviral API
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Dasabuvir-d6
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| Category | Hepatitis C Virus (HCV) |
| CAS | 2158336-69-5 |
| Description | Dasabuvir-d6 (ABT-333-d6) is the deuterium labeled Dasabuvir. Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene, inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC50 between 2.2 and 10.7 nM. |
Product Information
| Synonyms | Dasabuvir-d6|CS-0371320 |
| Molecular Weight | 499.61 |
| Molecular Formula | C26H27N3O5S |
| Canonical SMILES | CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O |
| Purity | ≥98% (HPLC) |
| Solubility | In vitro: 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 938 |
| Exact Mass | 499.20480262 |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs. |
| PSA | 106.61000 |
| Target | HCV |
| XLogP3-AA | 4.3 |
