Dasabuvir-d6

Category	Hepatitis C Virus (HCV)
CAS	2158336-69-5
Description	Dasabuvir-d6 (ABT-333-d6) is the deuterium labeled Dasabuvir. Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the HCV NS5B gene, inhibits recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with IC50 between 2.2 and 10.7 nM.

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Synonyms	Dasabuvir-d6\|CS-0371320
Molecular Weight	499.61
Molecular Formula	C26H27N3O5S
Canonical SMILES	CC(C)(C)C1=CC(=CC(=C1OC)C2=CC3=C(C=C2)C=C(C=C3)NS(=O)(=O)C)N4C=CC(=O)NC4=O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	938
Exact Mass	499.20480262
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
PSA	106.61000
Target	HCV
XLogP3-AA	4.3