-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Dapivirine-[d11]
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 1329613-10-6 |
| Description | Dapivirine-[d11], is the labelled analogue of Dapivirine. Dapivirine is a NNRTI for HIV reverse transcriptase with IC50 of 24 nM, inhibiting a broad panel of HIV-1 isolates from different classes, inclucing a wide range of NNRTI-resistant isolates. |
Product Information
| Synonyms | 4-[[4-[(2,4,6-Trimethylphenyl-d11)amino]-2-pyrimidinyl]amino]benzonitrile; Dapivirine D11 |
| IUPAC Name | 4-[[4-[3,5-dideuterio-2,4,6-tris(trideuteriomethyl)anilino]pyrimidin-2-yl]amino]benzonitrile |
| Molecular Weight | 340.47 |
| Molecular Formula | C20H8D11N5 |
| Canonical SMILES | CC1=CC(=C(C(=C1)C)NC2=NC(=NC=C2)NC3=CC=C(C=C3)C#N)C |
| InChI | InChI=1S/C20H19N5/c1-13-10-14(2)19(15(3)11-13)24-18-8-9-22-20(25-18)23-17-6-4-16(12-21)5-7-17/h4-11H,1-3H3,(H2,22,23,24,25)/i1D3,2D3,3D3,10D,11D |
| InChIKey | ILAYIAGXTHKHNT-UXJCIKOESA-N |
| Boiling Point | 557.9±60.0 °C at 760 mmHg |
| Melting Point | 217-219°C |
| Flash Point | 291.2±32.9 °C |
| Purity | 96% (CP); 98% atom D |
| Density | 1.2±0.1 g/cm3 |
| Solubility | Soluble in DMSO, Methanol |
| Appearance | Light Brown Solid |
| Storage | Store at -20°C |
| Complexity | 452 |
| Exact Mass | 340.23308983 |
| Index Of Refraction | 1.649 |
| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs. |
| Target | HIV; Reverse Transcriptase; Apoptosis; Autophagy |
| Vapor Pressure | 0.0±1.5 mmHg at 25°C |
| XLogP3-AA | 4.8 |
