Danshensu

Category	SARS-CoV
CAS	76822-21-4
Description	Danshensu is an active component of Salvia miltiorrhiza that shows wide cardiovascular benefit. It suppresses the formation of reactive oxygen species and inhibits platelet adhesion and aggregation. It also protects myocardium from the reperfusion injury and inhibits apoptosis of H9c2 cardiomyocytes via Akt and ERK1/2 phosphorylation. It increases production of collagenin Detroit 551 cells and attenuates the α-MSH-stimulated melanin production of B16 cells. It may be used as active ingredients in would healing, cosmetic treatments or treating hyperpigmentation. It significantly decreased the level of the marker enzymes (creatine kinase and lactate dehydrogenase) from the coronary effluents and myocardial infarction size in vitro. It also had ROS scavenging activity and boosted endogenous antioxidants such as SOD, CAT, MDA, GSH-PX and HO-1 activities by activating nuclear factor erythroid-2-related factor 2 (Nrf2) signaling pathway which was mediated by Akt and ERK1/2 in western blot analysis. It significantly lowered tHcy in rats with elevated tHcy. Danshensu is a natural compound, which can also be used in cosmetics material.

Quotation Now

Synonyms	Danshensu;76822-21-4;Salvianic acid A;(R)-3-(3,4-Dihydroxyphenyl)-2-hydroxypropanoic acid;Dan shen suan A;Salianic acid A;(2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid;UNII-4GF33A5PAJ;DS-182;4GF33A5PAJ;Benzenepropanoic acid, alpha,3,4-trihydroxy-, (alphaR)-;CHEMBL4218391;DTXSID60469215;Benzenepropanoic acid, a,3,4-trihydroxy-, (aR)-;(2R)-3-(3,4-dihydroxyphenyl)lactic acid;(2~{R})-3-[3,4-bis(oxidanyl)phenyl]-2-oxidanyl-propanoic acid;(R)-3-(3,4-dihydroxyphenyl)lactate;Dan shen suan A;Salvianic acid A;SCHEMBL18469325;CHEBI:71572;DTXCID70420034;BCP28285;HY-N1913;BDBM50594969;MFCD09750417;s4741;AKOS006328573;AC-7985;CCG-266569;CS-5614;NCGC00507734-01;AS-67314;DA-52304;C22038;r-(+)-beta-(3,4-dihydroxyphenyl)-lactic acid;A865407;W-203757;Q10395557;BENZENEPROPANOIC ACID, .ALPHA.,3,4-TRIHYDROXY-, (.ALPHA.R)-;(R)-a,3,4-Trihydroxybenzenepropanoic acid; 3-(3',4'-Dihydroxyphenyl)-(2R)-lactic acid; Dan shen suan A; Salvianic acid A;Danshensu;TO9;
IUPAC Name	(2R)-3-(3,4-dihydroxyphenyl)-2-hydroxypropanoic acid
Molecular Weight	198.17
Molecular Formula	C9H10O5
Canonical SMILES	OC1=C(C=CC(C[C@H](C(O)=O)O)=C1)O
InChI	InChI=1S/C9H10O5/c10-6-2-1-5(3-7(6)11)4-8(12)9(13)14/h1-3,8,10-12H,4H2,(H,13,14)/t8-/m1/s1
InChIKey	PAFLSMZLRSPALU-MRVPVSSYSA-N
Boiling Point	481.5±40.0°C at 760 mmHg
Melting Point	>270°C (dec.)
Purity	>98%
Density	1.546±0.06 g/cm3
Solubility	Soluble in DMSO (Slightly), Water (Slightly)
Appearance	Solid
Shelf Life	2 month in rt, long time
Storage	Store at 2-8°C under inert atmosphere