Cyclic-HPMPC

Category	Orthopoxvirus
CAS	127757-45-3
Description	Cyclic HPMPC is a potent antiviral agent. Cyclic HPMPC can increase arterial oxygen saturation levels in lethal vaccinia virus (IHD strain)-infected mice. Cyclic HPMPC improves the outcome of congenital guinea pig cytomegalovirus (GPCMV) infection and decreases viral replication in guinea pig model.

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Synonyms	Chpmpc\|cCDV\|Cyclic-hpmpc\|Cyclic HPMPC\|CYCLIC CIDOFOVIR\|Cyclic(S)-HPMPC\|127757-45-3\|UNII-BO8PRP86RH\|BO8PRP86RH\|Cyclic-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine\|GS 930\|1-((2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl)cytosine\|(S)-4-Amino-1-((2-hydroxy-1,4,2-dioxaphosphorinan-5-yl)methyl)-2(1H)-pyrimidinone P-oxide\|cyclic HPMPC, GS 0930\|SCHEMBL140858\|CHEMBL392630\|DTXSID00155660\|BDBM50485549\|2(1H)-Pyrimidinone, 4-amino-1-((2-hydroxy-1,4,2-dioxaphosphorinan-5-yl)methyl)-, P-oxide, (S)-\|HY-147014\|1-[((5)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine\|1-[((s)-2-hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl]cytosine\|1-[[(S)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinane-5-yl]methyl]cytosine\|1-(((S)-2-Hydroxy-2-oxo-1,4,2-dioxaphosphorinan-5-yl)methyl)cytosine (cyclic HPMPC)\|(5S)-5-[(4-Amino-1,2-dihydro-2-oxopyrimidine-1-yl)methyl]-2-hydroxy-1,4,2-dioxaphosphorinane 2-oxide\|4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2$l^{5}-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one\|4-amino-1-[[(5S)-2-hydroxy-2-oxo-1,4,2lambda5-dioxaphosphinan-5-yl]methyl]pyrimidin-2-one
Molecular Weight	261.17
Molecular Formula	C8H12N3O5P
Canonical SMILES	C1C(OCP(=O)(O1)O)CN2C=CC(=NC2=O)N
Boiling Point	495.6°C at 760mmHg
Flash Point	253.5°C
Purity	≥98% (HPLC)
Density	1.83g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	435
Exact Mass	261.05145749
Index Of Refraction	1.709
PSA	127.47000
Target	CMV; Orthopoxvirus
Vapor Pressure	3.57E-11mmHg at 25°C
XLogP3-AA	-2.6