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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Clevudine
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| Category | Hepatitis B Virus (HBV) |
| CAS | 163252-36-6 |
| Description | Clevudine is an inhibitor of hepatitis B virus (HBV). It is metabolized in cells by the cellular thymidine kinase as well as deoxycytidine kinase to its monophosphate, and subsequently to the di- and triphosphate, which are biologically active. |
Product Information
| Synonyms | 1-(2'-Deoxy-2'-fluoro-β-L-arabinofuranosyl)-5-methyluracil; L-FMAU; 1-(2-Deoxy-2-fluoro-β-L-arabinofuranosyl)-5-methyl-2,4(1H,3H)-pyrimidinedione; L FMAU; LFMAU; Levovir; 2'-Fluoro-5-methyl-b-L-arabinofuranosyluracil |
| IUPAC Name | 1-[(2S,3R,4S,5S)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-methylpyrimidine-2,4-dione |
| Molecular Weight | 260.22 |
| Molecular Formula | C10H13FN2O5 |
| Canonical SMILES | CC1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F |
| InChI | InChI=1S/C10H13FN2O5/c1-4-2-13(10(17)12-8(4)16)9-6(11)7(15)5(3-14)18-9/h2,5-7,9,14-15H,3H2,1H3,(H,12,16,17)/t5-,6+,7-,9-/m0/s1 |
| InChIKey | GBBJCSTXCAQSSJ-XQXXSGGOSA-N |
| Melting Point | 184-185 °C |
| Purity | ≥98% by HPLC |
| Density | 1.55±0.1 g/cm3 |
| Solubility | Soluble in DMSO (Slightly), Methanol (Slightly) |
| Appearance | White Solid |
| Application | Antiviral Agents |
| Storage | Store at -20°C |
| Complexity | 413 |
| Exact Mass | 260.08084968 |
| Index Of Refraction | 1.592 |
| In Vitro | Clevudine (L-FMAU) shows some activity against Epstein-Barr virus. |
| PSA | 104.55000 |
| Target | HBV; DNA/RNA Synthesis; Orthopoxvirus |
| XLogP3-AA | -0.9 |
