Cletoquine-d4-1

Category	Influenza Virus
CAS	1216461-56-1
Description	Cletoquine-d4-1 (Desethylhydroxychloroquine-d4-1) is the deuterium labeled Cletoquine. Cletoquine (Desethylhydroxychloroquine) is a major active metabolite of Hydroxychloroquine. Cletoquine is produced in the liver by CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine is also a Chloroquine derivative and has the ability to against the chikungunya virus (CHIKV). Cletoquine has antimalarial effects and has the potential for autoimmune diseases treatment.

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Synonyms	Cletoquine-d4-1\|HY-135810S1\|CS-0369580
Molecular Weight	311.84
Molecular Formula	C16H22ClN3O
Canonical SMILES	CC(CCCNCCO)NC1=C2C=CC(=CC2=NC=C1)Cl
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	293
Exact Mass	311.1702470
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
PSA	131.78000
Target	Influenza Virus; Parasite
XLogP3-AA	2.7