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Antiviral API
- Arenavirus
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- Antiviral intermediates
Clemastanin B
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| Category | Influenza Virus |
| CAS | 112747-98-5 |
| Description | Clemastanin B is found in the root of Clematis stans (Ranunculaceae), Eucommia sp. and Galium sinaicum, it has antioxidant and anti-inflammatory activities. |
Product Information
| Synonyms | Clemastanin B|112747-98-5|(2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-[4-[[(3R,4R,5S)-4-(hydroxymethyl)-5-[3-methoxy-4-[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyphenyl]oxolan-3-yl]methyl]-2-methoxyphenoxy]oxane-3,4,5-triol|HY-N6025|CS-0032192|LAriciresinol 4,4'-bis-O-|A-D-glucopyranoside |
| Molecular Weight | 684.68 |
| Molecular Formula | C32H44O16 |
| Canonical SMILES | COC1=C(C=CC(=C1)CC2COC(C2CO)C3=CC(=C(C=C3)OC4C(C(C(C(O4)CO)O)O)O)OC)OC5C(C(C(C(O5)CO)O)O)O |
| InChI | InChI=1S/C32H44O16/c1-42-20-8-14(3-5-18(20)45-31-28(40)26(38)24(36)22(11-34)47-31)7-16-13-44-30(17(16)10-33)15-4-6-19(21(9-15)43-2)46-32-29(41)27(39)25(37)23(12-35)48-32/h3-6,8-9,16-17,22-41H,7,10-13H2,1-2H3/t16-,17-,22+,23+,24+,25+,26-,27-,28+,29+,30+,31+,32+/m0/s1 |
| InChIKey | PBLWZMSRSJTRHJ-NCIRKIHRSA-N |
| Boiling Point | 922.6±65.0 °C at 760 mmHg |
| Flash Point | 511.8±34.3 °C |
| Purity | > 95% |
| Density | 1.5±0.1 g/cm3 |
| Solubility | DMSO; Pyridine; Methanol; Ethanol |
| Appearance | Powder |
| Storage | Desiccate at -20°C |
| Complexity | 978 |
| Exact Mass | 684.26293531 |
| Index Of Refraction | 1.630 |
| In Vitro | Clemastanin B inhibits different subtypes of human (H1N1, including swine-origin H1N1; H3N2 and influenza B) and avian Influenza Viruses (H6N2, H7N3, H9N2) at different magnitudes of activity (IC50 0.087-0.72 mg/ml) while this compound was inactive against respiratory syncytial virus (RSV), adenovirus 3 (ADV3), parainfluenza virus 3 (PIV3), enterovirus 71 (EV71) and human rhinovirus (HRV). Clemastanin B (0.05, 0.1, 0.2, 0.4 mg/ml; for 8 hours) treatment results in nucleoprotein (NP) distribution in the nuclei in MDCK cells. Clemastanin B (48-72 h) after virus incubation (MOI, 0.01; for 2 h) causes a pronounced titer reduction of progeny virus in MDCK cells. Clemastanin B (pre-incubated for 2 h) has no protective effect on MDCK cell lines with influenza virus. |
| Target | Influenza Virus |
| Vapor Pressure | 0.0±0.3 mmHg at 25°C |
| XLogP3-AA | -1.2 |
