Chloro Sofosbuvir

Category	Hepatitis C Virus (HCV)
CAS	1496552-51-2
Description	Chloro Sofosbuvir is an impurity of Sofosbuvir; a prodrug that is metabolized to the active antiviral agent 2'-deoxy-2'-α-fluoro-β-C-methyluridine-5'-monophosphate and is currently being investigated in phase 3 clinical trials for the treatment of hepatitis C. Studies have profiled Sofosbuvir as a nucleotide inhibitor of hepatitis C virus, exerting selective inhibitory effects towards HCV NS5B polymerase.

Quotation Now

Synonyms	N-[[P(S),2'R]-2'-Chloro-2'-deoxy-2'-methyl-P-phenyl-5'-uridylyl]-L-alanine 1-Methylethyl Ester
IUPAC Name	propan-2-yl 2-[[[4-chloro-5-(2,4-dioxopyrimidin-1-yl)-3-hydroxy-4-methyloxolan-2-yl]methoxy-phenoxyphosphoryl]amino]propanoate
Molecular Weight	545.91
Molecular Formula	C22H29ClN3O9P
Canonical SMILES	CC(C)OC(=O)C(C)NP(=O)(OCC1C(C(C(O1)N2C=CC(=O)NC2=O)(C)Cl)O)OC3=CC=CC=C3
InChI	InChI=1S/C22H29ClN3O9P/c1-13(2)33-19(29)14(3)25-36(31,35-15-8-6-5-7-9-15)32-12-16-18(28)22(4,23)20(34-16)26-11-10-17(27)24-21(26)30/h5-11,13-14,16,18,20,28H,12H2,1-4H3,(H,25,31)(H,24,27,30)
InChIKey	SFPFZQKYPOWCSI-UHFFFAOYSA-N
Purity	≥98% (HPLC)
Density	1.4±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	913
Exact Mass	545.1329942
Index Of Refraction	1.588
Target	HCV
XLogP3-AA	1.2