Cephalotaxine

Category	Influenza Virus
CAS	24316-19-6
Description	Antiviral and antitumor agent.

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Synonyms	(-)-Cephalotaxine; ZINC19795976
IUPAC Name	(2S,3S,6R)-4-methoxy-16,18-dioxa-10-azapentacyclo[11.7.0.02,6.06,10.015,19]icosa-1(20),4,13,15(19)-tetraen-3-ol
Molecular Weight	315.36
Molecular Formula	C18H21NO4
Canonical SMILES	COC1=CC23CCCN2CCC4=CC5=C(C=C4C3C1O)OCO5
InChI	InChI=1S/C18H21NO4/c1-21-15-9-18-4-2-5-19(18)6-3-11-7-13-14(23-10-22-13)8-12(11)16(18)17(15)20/h7-9,16-17,20H,2-6,10H2,1H3/t16-,17-,18+/m1/s1
InChIKey	YMNCVRSYJBNGLD-KURKYZTESA-N
Boiling Point	495.2±45.0 °C at 760 mmHg
Flash Point	253.3±28.7 °C
Purity	>98%
Density	1.4±0.1 g/cm3
Solubility	In Vitro: DMSO : 25 mg/mL(79.27 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (7.93 mM); Clear solution
Appearance	Powder
Application	antiviral; antitumor
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	523
Exact Mass	315.14705815
Index Of Refraction	1.665
In Vitro	Cephalotaxine inhibits Zika infection by impeding viral replication and stability.
PSA	51.16000
Target	Influenza Virus: ZIKV
Vapor Pressure	0.0±1.3 mmHg at 25°C
XLogP3-AA	0.2