Catechin

Category	Influenza Virus
CAS	154-23-4
Description	(+)-Catechin is a flavonoid found primarily in higher woody plants as (+)-Catechin along with (-)-Epicatechin (cis form). Antidiarrheal.

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Product Information

Synonyms	(+)-Catechin; Cianidanol; D-Catechin; Cyanidanol; Catechuic acid; KB 53; KB-53; KB53; NSC 2819; Z 7300; NSC2819; Z7300; NSC-2819; Z-7300
Molecular Weight	290.27
Molecular Formula	C15H14O6
Canonical SMILES	C1C(C(OC2=CC(=CC(=C21)O)O)C3=CC(=C(C=C3)O)O)O
InChI	InChI=1S/C15H14O6/c16-8-4-11(18)9-6-13(20)15(21-14(9)5-8)7-1-2-10(17)12(19)3-7/h1-5,13,15-20H,6H2/t13-,15+/m0/s1
InChIKey	PFTAWBLQPZVEMU-DZGCQCFKSA-N
Boiling Point	630.4±55.0 °C at 760 mmHg
Melting Point	175-177°C (anhydrous)(lit.)
Flash Point	335.0±31.5 °C
Purity	>98%
Density	1.593 g/cm3
Solubility	In Vitro: DMSO : ≥ 100 mg/mL(344.51 mM) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (8.61 mM); Clear solution
Appearance	Powder
Application	antiulcer; antioxidant
Storage	4°C, sealed storage, away from moisture and light * In solvent : -80°C 6 months; -20°C 1 month (sealed storage, away from moisture and light)
Complexity	364
Exact Mass	290.07903816
Index Of Refraction	1.742
In Vitro	Catechin ((+)-Catechin) exhibits >95% inhibitory activity at 70 μg/mL against cyclooxygenase-1 (COX-1) with an IC50 of 1.4 μM. A dose-dependent reduction in color is observed after 24 hours of treatment with Catechin, and 54.76% of the cells are dead at the highest concentration of Catechin tested (160 μg/mL) whereas the IC50 of Catechin is achieved at 127.62 μg/mL Catechin. A dose- and time-dependent increase in the induction of Apoptosis is observed when MCF-7 cells are treated with Catechin. When compare to the control cells at 24 hours, 40.7 and 41.16% of the cells treated with 150 μg/mL and 300 μg/mL Catechin, respectively, undergo Apoptosis. The expression levels of Caspase-3, -8, and -9 and p53 in MCF-7 cells treated with 150 μg/mL Catechin for 24 h increase by 5.81, 1.42, 3.29, and 2.68 fold, respectively, as compare to the levels in untreated control cells.
In Vivo	Animals treated with Catechin ((+)-Catechin) at the lowest tested dose, i.e., 50 mg/kg, p.o. have spent comparatively more time in exploring the novel object in the choice trial, however, the difference is not statistically significant. Catechin prevents the time-induced episodic memory deficits in a dose-dependent manner, the most effective being 200 mg/kg, p.o.. Treatment with Catechin prevents the rise in MPO level compare to DOX alone treatment group (21.98±9.44 and 36.76±4.39% in the hippocampus and the frontal cortex respectively).
PSA	110.38000
Target	COX; Apoptosis; Influenza Virus; Endogenous Metabolite
Vapor Pressure	0.0±1.9 mmHg at 25°C
XLogP3-AA	0.4