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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
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- Endogenous Metabolite
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- West Nile virus
- Antiviral intermediates
Cap-dependent-endonuclease-IN-26
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| Category | Influenza Virus |
| CAS | 1370238-26-8 |
| Description | Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains. |
Product Information
| Synonyms | CHEMBL4465872|Cap-dependent endonuclease-IN-26|SCHEMBL10290014|TQR1119|BDBM50508964|HY-143781|CS-0375184 |
| Molecular Weight | 389.45 |
| Molecular Formula | C23H23N3O3 |
| Canonical SMILES | CC(C)N1CN(N2C=CC(=O)C(=C2C1=O)O)C(C3=CC=CC=C3)C4=CC=CC=C4 |
| Purity | ≥98% (HPLC) |
| Solubility | 10 mM in DMSO |
| Appearance | Solid powder |
| Storage | Store at -20°C |
| Complexity | 684 |
| Exact Mass | 389.17394160 |
| In Vitro | Cap-dependent endonuclease-IN-26 (compound 2v) exhibits broad antiviral spectrum. Cap-dependent endonuclease-IN-26 shows antiviral activity against the H1N1 type, including the reverse genetic strain (rgA/WSN/33), oseltamivir-resistant strain (rgA/WSN/33-NA/H274Y), clinically isolated strain (A/PR/8/34), H3N2 A/Victoria/3/75, H3N2 A/HongKong/8/68, influenza B/Hong Kong/5/72, and influenza B/Maryland/1/59 with EC50 values 165.1 nM, 80.4 nM, 183.0 nM, 828.8 nM, 301.5 nM, 124.3 nM, and 176.0 nM, respectively. |
| Target | Influenza Virus |
| XLogP3-AA | 4.4 |
