BX-513 hydrochloride

Category	Cytomegalovirus (CMV)
CAS	1216540-18-9
Description	BX 513 hydrochloride is a selective CCR1 receptor antagonist (Ki = 0.04, > 10, > 10 and > 10 nM for CCR1, CCR5, CXCR2 and CXCR4 receptors, respectively), and also acts as a US28 agonist. It inhibits MIP-1α-induced intracellular calcium mobilization (IC50 = 2.5 μM).

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Synonyms	BX 513 hydrochloride;193542-65-3;1216540-18-9;BX-513 HCl;BX513Hydrochloride;VUF 2274;BX-513;5-[4-(4-CHLOROPHENYL)-4-HYDROXYPIPERIDIN-1-YL]-2,2-DIPHENYLPENTANENITRILE HYDROCHLORIDE;5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile;hydrochloride;BX-513 hydrochloride;4-(4-CHLOROPHENYL)-4-HYDROXY-A,A-DIPHENYL-1-PIPERIDINEPENTANENITRILE HYDROCHLORIDE;BX 513 HCL;DTXSID30719335;BCP27909;AKOS024457285;AS-57268;VUF 2274;VUF2274; BX513 hydrochloride; BX-513 hydrochloride;1-Piperidinepentanenitrile,4-(4-chlorophenyl)-4-hydroxy-a,a-diphenyl-,HCl;5-[4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile--hydrogen chloride (1/1);
IUPAC Name	5-[4-(4-chlorophenyl)-4-hydroxypiperidin-1-yl]-2,2-diphenylpentanenitrile;hydrochloride
Molecular Weight	481.46
Molecular Formula	C28H30Cl2N2O
Canonical SMILES	N#CC(C1=CC=CC=C1)(C2=CC=CC=C2)CCCN3CCC(O)(C4=CC=C(Cl)C=C4)CC3.[H]Cl
InChI	InChI=1S/C28H29ClN2O.ClH/c29-26-14-12-25(13-15-26)28(32)17-20-31(21-18-28)19-7-16-27(22-30,23-8-3-1-4-9-23)24-10-5-2-6-11-24;/h1-6,8-15,32H,7,16-21H2;1H
InChIKey	SSZWNUGWOGONQJ-UHFFFAOYSA-N
Purity	≥99% by HPLC
Solubility	Soluble in DMSO, Ethanol
Appearance	White Solid
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.