-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
BMS-663068
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 864953-29-7 |
| Description | BMS-663068 is an HIV-1 attachment inhibitor in development for the treatment of HIV-1 infection. It is a prodrug for BMS-626529, which binds to the viral envelope glycoprotein gp120 and interferes with attachment of the virus to the cellular CD4 receptor. |
Product Information
| Synonyms | Fostemsavir; BMS-663068; BMS 663068; BMS663068 |
| Molecular Weight | 583.49 |
| Molecular Formula | C25H26N7O8P |
| Canonical SMILES | CC1=NN(C=N1)C2=NC=C(C3=C2N(C=C3C(=O)C(=O)N4CCN(CC4)C(=O)C5=CC=CC=C5)COP(=O)(O)O)OC |
| InChI | InChI=1S/C25H26N7O8P/c1-16-27-14-32(28-16)23-21-20(19(39-2)12-26-23)18(13-31(21)15-40-41(36,37)38)22(33)25(35)30-10-8-29(9-11-30)24(34)17-6-4-3-5-7-17/h3-7,12-14H,8-11,15H2,1-2H3,(H2,36,37,38) |
| InChIKey | SWMDAPWAQQTBOG-UHFFFAOYSA-N |
| Boiling Point | 904.1±75.0 °C at 760 mmHg |
| Flash Point | 500.6±37.1 °C |
| Purity | >98% |
| Density | 1.6±0.1 g/cm3 |
| Solubility | In Vitro: DMSO : ≥ 100 mg/mL(171.38 mM) H2O : 20 mg/mL(34.28 mM;Need ultrasonic) |
| Appearance | White to off-white (Solid) |
| Storage | Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month |
| Complexity | 1020 |
| Exact Mass | 583.15804781 |
| Index Of Refraction | 1.723 |
| In Vivo | Fostemsavir (BMS-663068) has good antiviral activity in subjects infected with virus shown to be susceptible (IC50, <100 nM) to the agent. |
| PSA | 192.02000 |
| Target | HIV |
| Vapor Pressure | 0.0±0.3 mmHg at 25°C |
| XLogP3-AA | -0.1 |
