BLT-1

Category	Hepatitis C Virus (HCV)
CAS	321673-30-7
Description	BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor.

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Product Information

Synonyms	2-Hexyl-1-cyclopentanone thiosemicarbazone, 33M20, BLT1, Block lipid transport-1, MIT 9952-53
IUPAC Name	[(E)-(2-hexylcyclopentylidene)amino]thiourea
Molecular Weight	241.40
Molecular Formula	C12H23N3S
Canonical SMILES	CCCCCCC1CCCC1=NNC(=S)N
InChI	InChI=1S/C12H23N3S/c1-2-3-4-5-7-10-8-6-9-11(10)14-15-12(13)16/h10H,2-9H2,1H3,(H3,13,15,16)/b14-11+
InChIKey	OWGUSBISUVLUJF-SDNWHVSQSA-N
Purity	98.83%
Solubility	In Vitro: DMSO : 41.67 mg/mL(172.62 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: 2.08 mg/mL (8.62 mM); Suspended solution; Need ultrasonic 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution
Appearance	Off-white to light yellow (Solid)
Storage	Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Complexity	251
Exact Mass	241.16126892
In Vitro	BLT-1 has IC50s of 60 and 110 nM for cellular DiI-HDL and [3H]CE-HDL uptake in ldlA[mSR-BI] cells. BLT-1 has an IC50 of 0.96 μM for the HCV entry in Huh 7.5.1 cells. BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells. BLT-1 can inhibit SR-BI-dependent selective uptake of [3H]CE from [3H]CE-HDL by mSR-BI-t1 containing liposomes in cells (IC50=0.057 µM) and liposomes (IC50=0.098 µM).
PSA	87.04000
Target	HCV
XLogP3-AA	3.3