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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
BIO-acetoxime
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| Category | Herpes simplex Virus (HSV) |
| CAS | 667463-85-6 |
| Description | BIO-acetoxime is a potent and selective GSK-3 inhibitor, with IC50s of both 10 nM for GSK-3α/β. It shows >240-fold selectivity over CDK5/p25, CDK2/cyclin A and CDK1/cyclin B. It has anticonvulsant and anti-infection activity. |
Product Information
| Synonyms | BIA; GSK-3 Inhibitor X; (2'Z,3'E)-6-Bromoindirubin-3'-acetoxime; (3Z)-3-[(3E)-3-(Acetoxyimino)-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-2H-indol-2-one; 2H-Indol-2-one, 3-[(3E)-3-[(acetyloxy)imino]-1,3-dihydro-2H-indol-2-ylidene]-6-bromo-1,3-dihydro-, (3Z)-; 6-Bromoindirubin acetoxime; 6-Bromoindirubin-3'-acetoxime |
| IUPAC Name | (2Z,3E)-3-(acetoxyimino)-6'-bromo-[2,3'-biindolinylidene]-2'-one |
| Molecular Weight | 398.21 |
| Molecular Formula | C18H12BrN3O3 |
| Canonical SMILES | CC(=O)ON=C1C2=CC=CC=C2N=C1C3=C(NC4=C3C=CC(=C4)Br)O |
| InChI | InChI=1S/C18H12BrN3O3/c1-9(23)25-22-16-12-4-2-3-5-13(12)20-17(16)15-11-7-6-10(19)8-14(11)21-18(15)24/h2-8,20H,1H3,(H,21,24)/b17-15-,22-16+ |
| InChIKey | MENDIXKFTXYTHJ-HPBPSMLHSA-N |
| Purity | 98% |
| Density | 1.69±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO, Ethanol, Water |
| Appearance | Dark Red to Purple Powder |
| Shelf Life | 2 years if stored properly |
| Storage | Store at 2-8°C |
| Animal Admin | Male FVB/N mice are used to test the anticonvulsant effects of BIO-acetoxime in fully kindled mice. To achieve the fully kindled state, mice are stimulated at a fixed subconvulsive threshold current twice daily. The anticonvulsant effect of BIO-acetoxime (BIA) is investigated in the "epileptic" fully kindled mice by stimulating these animals on Monday morning. |
| Complexity | 608 |
| Exact Mass | 397.00620 |
| Index Of Refraction | 1.741 |
| PSA | 83.28000 |
| Target | GSK-3; Apoptosis; HSV |
| XLogP3-AA | 3.8 |
