(±)-BI-D

Category	HIV Protease
CAS	1416258-16-6
Description	Approximately 2.4-2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160-200 nM, in Psip1 and double-KO cells.

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Synonyms	(±)-BI-D; BI-D; BI D; BID
IUPAC Name	2-[4-(3,4-dihydro-2H-chromen-6-yl)-2-methylquinolin-3-yl]-2-[(2-methylpropan-2-yl)oxy]acetic acid
Molecular Weight	405.49
Molecular Formula	C25H27NO4
Canonical SMILES	CC1=NC2=CC=CC=C2C(=C1C(C(=O)O)OC(C)(C)C)C3=CC4=C(C=C3)OCCC4
InChI	InChI=1S/C25H27NO4/c1-15-21(23(24(27)28)30-25(2,3)4)22(18-9-5-6-10-19(18)26-15)17-11-12-20-16(14-17)8-7-13-29-20/h5-6,9-12,14,23H,7-8,13H2,1-4H3,(H,27,28)
InChIKey	ZFERZAMPQIXCPM-UHFFFAOYSA-N
Boiling Point	587.3±50.0 °C at 760 mmHg
Flash Point	309.0±30.1 °C
Purity	>98%
Density	1.2±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Light yellow to yellow (Solid)
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Index Of Refraction	1.610
In Vitro	Approximately 2.4-2.9 μM of BI-D was required to inhibit 50% of HIV-Luc infection of WT and Hdgfrp2 KO cells, while the IC50 decreased dramatically, to 160-200 nM, in Psip1 and double-KO cells
Target	HIV; HIV Integrase
Vapor Pressure	0.0±1.7 mmHg at 25°C