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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Orthopoxvirus
- Others
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Virus Protease
- Antiviral intermediates
BI-653048-phosphate
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| Category | HCV Protease |
| CAS | 1198784-97-2 |
| Description | BI 653048 phosphate is a selective and orally active nonsteroidal glucocorticoid (GC) agonist with an IC50 value of 55 nM. |
Product Information
| Synonyms | UNII-DCS4MDS87R|DCS4MDS87R|1198784-97-2|BI 653048 (phosphate)|(R)-2-(4-((5-(Ethylsulfonyl)-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide phosphate|2-[(4R)-4-[(5-ethylsulfonyl-1H-pyrrolo[2,3-c]pyridin-2-yl)methyl]-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl]-5-fluorobenzamide;phosphoric acid|BI653048 phosphate|BI-653048 phosphate|SCHEMBL1493821|HY-12946A|CS-0021103|2-((3R)-3-((5-Ethylsulfonyl-1H-pyrrolo(2,3-C)pyridin-2-yl)methyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethyl-butyl)-5-fluoro-benzamide; phosphoric acid|2-((4R)-4-((5-(Ethanesulfonyl)-1H-pyrrolo(2,3-C)pyridin-2-yl)methyl)-5,5,5-trifluoro-4-hydroxy-2-methylpentan-2-yl)-5-fluorobenzamide; phosphoric acid|Benzamide, 2-((3R)-3-((5-(ethylsulfonyl)-1H-pyrrolo(2,3-C)pyridin-2-yl)methyl)-4,4,4-trifluoro-3-hydroxy-1,1-dimethylbutyl)-5-fluoro-, phosphate (1:1) |
| Molecular Weight | 613.52 |
| Molecular Formula | C23H28F4N3O8PS |
| Canonical SMILES | CCS(=O)(=O)C1=NC=C2C(=C1)C=C(N2)CC(CC(C)(C)C3=C(C=C(C=C3)F)C(=O)N)(C(F)(F)F)O.OP(=O)(O)O |
| Purity | >98.00% |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| Complexity | 929 |
| Exact Mass | 613.12708568 |
| In Vitro | BI 653048 phosphate exhibits an improved drug-like properties, inhibits CP1A2 ,CYP2D6 ,CYP2C9, CYP2C19 and CYP3A4 with IC50 values of 50 μM, 41 μM, 12 μM, 9 μM,and 8 μM, respectively. BI 653048 phosphate inhibits TNF-stimulated IL-6 production in mouse RAW cells with an IC50 value of 100 nM. BI 653048 phosphate reduces affinity for the hERG ion channel with an IC50>30 μM in recombinant HEK293 cells expressing the human ERG potassium channel. |
| In Vivo | BI 653048 phosphate (oral administration; 3, 10, and 30 mg/kg) at 3 mg/kg has nonsignificant decreases for all measured histology parameters (ankle inflammation, pannus formation, cartilage damage, and bone resorption). |
| Target | Glucocorticoid Receptor; Cytochrome P450; HCV Protease |
