-
Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
beta-L-D4A
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 7057-48-9 |
| Description | beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. |
Product Information
| Synonyms | 2'3'-Didehydro-2'3'-dideoxyadenosine; 2',3'-Dideoxy-2',3'-didehydroadenosine; Adenosine, 2',3'-didehydro-2',3'-dideoxy-; ((2S,5R)-5-(6-Amino-9H-purin-9-yl)-2,5-dihydrofuran-2-yl)methanol; 2'3'-Ddda; NSC 108602; 9-(2,3-Dideoxy-β-D-glycero-pent-2-enofuranosyl)adenine; Didanosine EP Impurity I |
| IUPAC Name | [(2S,5R)-5-(6-aminopurin-9-yl)-2,5-dihydrofuran-2-yl]methanol |
| Molecular Weight | 233.23 |
| Molecular Formula | C10H11N5O2 |
| Canonical SMILES | C1=CC(OC1CO)N2C=NC3=C(N=CN=C32)N |
| InChI | InChI=1S/C10H11N5O2/c11-9-8-10(13-4-12-9)15(5-14-8)7-2-1-6(3-16)17-7/h1-2,4-7,16H,3H2,(H2,11,12,13)/t6-,7+/m0/s1 |
| InChIKey | JFUOUIPRAAGUGF-NKWVEPMBSA-N |
| Boiling Point | 553.9±60.0°C (Predicted) |
| Melting Point | 187-189°C |
| Flash Point | 288.8°C |
| Purity | ≥95% |
| Density | 1.74±0.1 g/cm3 (Predicted) |
| Solubility | Soluble in DMSO |
| Appearance | Solid powder |
| Application | Anti-HIV Agents |
| Storage | Store at 2-8°C, protect from light |
| Complexity | 313 |
| Exact Mass | 233.09127461 |
| Index Of Refraction | 1.822 |
| In Vitro | beta-L-D4A is a nucleoside HIV-1 reverse transcriptase inhibitor. Results confirm that the biological activity of NSC 108602 is connected with the termination of the DNA chain synthesis in the 5'-3' direction. |
| PSA | 99.08000 |
| Target | HIV-1 |
| XLogP3-AA | -0.4 |
