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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Besifovir
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| Category | Hepatitis B Virus (HBV) |
| CAS | 441785-25-7 |
| Description | Besifovir is an orally available phosphonate nucleotide for the potential treatment of hepatitis B virus infection was well tolerated and also had a good clinical safety profile. |
Product Information
| Synonyms | LB 80380; LB80380; LB-80380;(1-((2-Amino-9H-purin-9-yl)methyl)cyclopropoxy)methylphosphonic acid;P-[[[1-[(2-amino-9H-purin-9-yl)methyl]cyclopropyl]oxy]methyl]-phosphonic acid |
| IUPAC Name | [1-[(2-aminopurin-9-yl)methyl]cyclopropyl]oxymethylphosphonic acid |
| Molecular Weight | 299.22 |
| Molecular Formula | C10H14N5O4P |
| Canonical SMILES | C1CC1(CN2C=NC3=CN=C(N=C32)N)OCP(=O)(O)O |
| InChI | 1S/C10H14N5O4P/c11-9-12-3-7-8(14-9)15(5-13-7)4-10(1-2-10)19-6-20(16,17)18/h3,5H,1-2,4,6H2,(H2,11,12,14)(H2,16,17,18) |
| InChIKey | KDNSSKPZBDNJDF-UHFFFAOYSA-N |
| Boiling Point | 711.9±60.0 °C at 760 mmHg |
| Flash Point | 384.3±32.9 °C |
| Purity | ≥98% |
| Density | 1.3±0.1 g/cm3 |
| Solubility | Soluble in DMSO |
| Appearance | White Solid |
| Application | DNA-directed DNA polymerase inhibitors; Hepatitis B virus replication inhibitors |
| Shelf Life | As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly. |
| Storage | Store at -20 °C |
| Complexity | 415 |
| Exact Mass | 299.07834094 |
| Index Of Refraction | 1.667 |
| In Vitro | Netarsodil (AR-13324) is a potent selective ROCK inhibitor with a Ki of 4.2 nM for ROCK2; Of a group of 422 kinases, 11 kinases were inhibited >90%, with only ROCK1 and ROCK2 (93% inhibition rate each) and PKC (δ, 91% and eta, 93% inhibited). |
| In Vivo | Besifovir exhibits improved bioavailability, showing effective and sustained IOP reduction 24 hours after administration. |
| Target | HBV |
| Vapor Pressure | 0.0±2.3 mmHg at 25°C |
| XLogP3-AA | -1.8 |
Description of First Aid Measures
Eye contact
Remove any contact lenses, locate eye-wash station, and flush eyes immediately with large amounts of water. Separate eyelids with fingers to ensure adequate flushing. Promptly call a physician.
Skin contactRinse skin thoroughly with large amounts of water. Remove contaminated clothing and shoes and call a physician.
InhalationImmediately relocate self or casualty to fresh air. If breathing is difficult, give cardiopulmonary resuscitation (CPR). Avoid mouth-to-mouth resuscitation.
IngestionWash out mouth with water; Do NOT induce vomiting; call a physician.