Bellidifolin

Category	Human immunodeficiency Virus (HIV)
CAS	2798-25-6
Description	Bellidifolin is a xanthone that can be isolated from the plants of Gentiana species. Study shows that bellidifolin is a potent hypoglycemic agent in streptozotocin (STZ)-induced diabetic rats from Swertia japonica. Bellidifolin may contribute to the protective effects associated with nerve injury initiated by hypoxia by mechanisms related to inhibition of cell apoptosis independent of the ERK pathway, but may involve blockade of p38MAPK signaling pathway activation and downstream caspase-3 expression.

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Synonyms	1,5,8-Trihydroxy-3-methoxy-9H-xanthen-9-one
IUPAC Name	1,5,8-trihydroxy-3-methoxyxanthen-9-one
Molecular Weight	274.228
Molecular Formula	C14H10O6
Canonical SMILES	COC1=CC(=C2C(=C1)OC3=C(C=CC(=C3C2=O)O)O)O
InChI	InChI=1S/C14H10O6/c1-19-6-4-9(17)11-10(5-6)20-14-8(16)3-2-7(15)12(14)13(11)18/h2-5,15-17H,1H3
InChIKey	JDIORNFCMMYMLF-UHFFFAOYSA-N
Boiling Point	580.2±50.0 °C at 760 mmHg
Melting Point	265-267°C
Flash Point	228.0±23.6 °C
Purity	98.5%
Density	1.6±0.1 g/cm3
Solubility	In vitro: 10 mM in DMSO
Appearance	Yellow powder
Storage	Powder: -20°C 3 years 4°C 2 years In solvent: -80°C 6 months -20°C 1 months
Complexity	386
Exact Mass	274.04773803
Index Of Refraction	1.714
PSA	100.13000
Target	HIV
Vapor Pressure	0.0±1.7 mmHg at 25°C
XLogP3-AA	2.4