Baloxavir-d5

Category	Influenza Virus
Description	Baloxavir-d5 is deuterium labeled Baloxavir. Baloxavir (Baloxavir acid), derived from the prodrug Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity.

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Synonyms	Baloxavir acid-d5; S-033447-d5
Molecular Weight	488.52
Molecular Formula	C24H14D5F2N3O4S
Canonical SMILES	O=C1N2[C@](COCC2)([H])N([C@]3([2H])C4=C([2H])C([2H])=C([2H])C([2H])=C4SCC5=C(F)C(F)=CC=C35)N6C1=C(O)C(C=C6)=O
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Complexity	932
Exact Mass	488.13781732
In Vitro	Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and Metabolic profiles of drugs.
Target	Influenza Virus
XLogP3-AA	3.6