Baicalein

Category	Influenza Virus
CAS	491-67-8
Description	Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. Baicalein is a CYP2C9 and prolyl endopeptidase inhibitor. Baicalein is a natural compound and can be used in cosmestics material.

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Product Information

Synonyms	5,6,7-Trihydroxyflavone; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one; NSC 661431; Noroxylin; 5,6,7-Trihydroxy-2-phenyl-4H-1-benzopyran-4-one
IUPAC Name	5,6,7-trihydroxy-2-phenylchromen-4-one
Molecular Weight	270.24
Molecular Formula	C15H10O5
Canonical SMILES	C1=CC=C(C=C1)C2=CC(=O)C3=C(C(=C(C=C3O2)O)O)O
InChI	InChI=1S/C15H10O5/c16-9-6-11(8-4-2-1-3-5-8)20-12-7-10(17)14(18)15(19)13(9)12/h1-7,17-19H
InChIKey	FXNFHKRTJBSTCS-UHFFFAOYSA-N
Boiling Point	575.9±50.0°C at 760 mmHg
Melting Point	256-271°C
Flash Point	225.3±23.6 °C
Purity	≥98%
Density	1.548 g/cm³
Solubility	Soluble in DMSO (Slightly), Methanol (Slightly)
Appearance	Light Yellow to Yellow Solid
Application	neuroprotective; anticancer
Storage	Store at -20°C
Complexity	413
Exact Mass	270.05282342
Index Of Refraction	1.732
In Vitro	Baicalein suppresses mitogen induced T cell proliferation and cytokine secretion in vitro. Baicalein treatment induces DNA binding of NF-κB but inhibits thioredoxin activity in the nuclear compartment. Baicalein significantly decreases the expression of SATB1 in MDA-MB-231 cells. Baicalein also downregulates the expression of Wnt1 and β-catenin proteins and transcription level of Wnt/β-catenin-targeted genes.
In Vivo	Baicalein suppresses induction of graft versus host disease but does not inhibit homeostatic proliferation of T-cells in mice. This observation clearly shows potent anti-inflammatory activity of baicalein in vivo. Baicalein can inhibit cardiac fibrosis in hypertensive rats.
PSA	90.90000
Target	Xanthine Oxidase; Influenza Virus; Ferroptosis
Vapor Pressure	0.0±1.7 mmHg at 25°C
XLogP3-AA	1.7