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AZT-triphosphate-TEA

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Category Hepatitis B Virus (HBV)
Description AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate TEA) is a active triphosphate metabolite of Zidovudine
(AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated Apoptosis pathway
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Product Information

Synonyms AZT triphosphate (TEA)|HY-116364A
Molecular Formula C16H31N6O13P3
Purity >98%
Solubility In vitro:
10 mM in DMSO
Appearance Solid powder
Storage Store at -20°C
Exact Mass 506.99600
In Vitro Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts.
PSA 303.09000
Target HIV
HBV
DNA polymerase
Reactive oxygen species (ROS)

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