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Antiviral API
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AZT triphosphate
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| Category | Hepatitis B Virus (HBV) |
| CAS | 92586-35-1 |
| Description | AZT triphosphate, an active triphosphate metabolite of Zidovudine (AZT), shows anti-retroviral activity, inhibits HIV replication, and also inhibits HBV DNA polymerase. It activates mitochondrial mediated apoptosis pathway. |
Product Information
| Synonyms | 3'-Azido-3'-deoxythymidine 5'-triphosphate; Zidovudine triphosphate; Combivir; AZTTP; Azt-TP; Azidothymidine triphosphate; Zidovudine 5'-triphosphate; 3'-Deoxy-3'-azidothymidine triphosphate; 3'-azido-3'-deoxythymidine 5'-(tetrahydrogen triphosphate); 1-(3'-Azido-2',3'-dideoxy-beta-D-xylofuranosyl)thymine 5'-triphosphate |
| IUPAC Name | [[(2S,3S,5R)-3-azido-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate |
| Molecular Weight | 507.18 |
| Molecular Formula | C10H16N5O13P3 |
| Canonical SMILES | CC1=CN(C(=O)NC1=O)C2CC(C(O2)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)N=[N+]=[N-] |
| InChI | InChI=1S/C10H16N5O13P3/c1-5-3-15(10(17)12-9(5)16)8-2-6(13-14-11)7(26-8)4-25-30(21,22)28-31(23,24)27-29(18,19)20/h3,6-8H,2,4H2,1H3,(H,21,22)(H,23,24)(H,12,16,17)(H2,18,19,20)/t6-,7+,8+/m0/s1 |
| InChIKey | GLWHPRRGGYLLRV-XLPZGREQSA-N |
| Purity | ≥95% |
| Solubility | Soluble in DMSO |
| Appearance | Solid |
| Storage | Store at -20°C |
| Exact Mass | 506.99600 |
| In Vitro | After 48 h of action by 100 μM zidovudine (AZT), the accumulation of AZT triphosphate (AZT-TP) in H9c2 cells disrupts the mitochondrial tubule network. AZT triphosphate accumulation leads to downregulation of Opa1 and upregulation of Drp1. AZT-triphosphate can cause mitochondrial dysfunction, increase the production of cytotoxic reactive oxygen species (ROS), and impair the balance of mitochondrial quality control systems in H9c2 cell models established from rat embryonic myoblasts. |
| PSA | 303.09000 |
| Target | HIV; DNA/RNA Synthesis; HBV; Reactive Oxygen Species; Apoptosis |
