Azithromycin dihydrate

Category	Influenza Virus
CAS	117772-70-0
Description	Azithromycin dihydrate is the dihydrate form of azithromycin, an orally bioavailable azalide derived from erythromycin, and a member of a subclass of macrolide antibiotics, with anti-bacterial activity. Azithromycin is marginally less active than erythromycin in vitro against Gram-positive organisms, although this is of doubtful clinical significance as susceptibility concentration fall within the range of achievable tissue Azithromycin concentrations.

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Product Information

Synonyms	Azitro; CP 62993; CP-62993; CP62993; Goxal; Odaz; Ribotrex; Toraseptol; Ultreon; XZ-450; XZ450; XZ 450; Zenstavion; Zithromax; Zmax
IUPAC Name	(2R,3S,4R,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-3,4,10-trihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one;dihydrate
Molecular Weight	785.02
Molecular Formula	C38H72N2O12.2H2O
Canonical SMILES	CCC1C(C(C(N(CC(CC(C(C(C(C(C(=O)O1)C)OC2CC(C(C(O2)C)O)(C)OC)C)OC3C(C(CC(O3)C)N(C)C)O)(C)O)C)C)C)O)(C)O.O.O
InChI	InChI=1S/C38H72N2O12.2H2O/c1-15-27-38(10,46)31(42)24(6)40(13)19-20(2)17-36(8,45)33(52-35-29(41)26(39(11)12)16-21(3)48-35)22(4)30(23(5)34(44)50-27)51-28-18-37(9,47-14)32(43)25(7)49-28;;/h20-33,35,41-43,45-46H,15-19H2,1-14H3;2*1H2/t20-,21-,22+,23-,24-,25+,26+,27-,28+,29-,30+,31-,32+,33-,35+,36-,37-,38-;;/m1./s1
InChIKey	SRMPHJKQVUDLQE-KUJJYQHYSA-N
Boiling Point	822.1°C at 760 mmHg
Melting Point	113-115°C
Flash Point	451°C
Purity	>98%
Density	1.18 g/cm3
Solubility	Soluble in DMSO
Appearance	White Solid
Application	Anti-Bacterial Agents
Storage	Store at -20°C
Complexity	1150
Exact Mass	784.529663
In Vitro	Azithromycin showed resistance to a range of similar spectrums of bacterial activity. It acts in vitro on gram-positive bacteria with slightly less activity than erythromycin, as the susceptible concentration drops to the concentration range of tissue Azithromycin, although this is clinically uncertain. Azithromycin is also anti-clinical isolates of anaerobic gram-positive bacteria cocci and propionibacterium acnes, with MIC90 of 2.3, 0.03 mg/L.
PSA	198.54000
Target	Influenza
Vapor Pressure	2.51E-31mmHg at 25°C