Azelastine HCl

Category	SARS-CoV
CAS	79307-93-0
Description	Azelastine HCl is a potent, second-generation, selective, histamine antagonist. It inhibits histamine via competing with histamine for the H1 receptor.

Quotation Now

Synonyms	ZELASTINE HYDROCHLORIDE; AC1Q1SYE; HYDROGEN AZELASTINE CHLORIDE; AKOS026749829; DR002552
IUPAC Name	4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one;hydrochloride
Molecular Weight	418.36
Molecular Formula	C22H25Cl2N3O
Canonical SMILES	[H+].CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.[Cl-]
InChI	InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H
InChIKey	YEJAJYAHJQIWNU-UHFFFAOYSA-N
Melting Point	223-225°C
Purity	>98%
Solubility	In Vitro: DMSO : 50 mg/mL(119.51 mM;Need ultrasonic) H2O : 6.67 mg/mL(15.94 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥ 2.5 mg/mL (5.98 mM); Clear solution
Appearance	White Solid
Application	histamine antagonist
Storage	4°C, sealed storage, away from moisture * In solvent : -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture)
Complexity	558
Exact Mass	417.137482
PSA	38.13000
Target	Histamine Receptor; SARS-CoV