Azelastine

Category	SARS-CoV
CAS	58581-89-8
Description	Azelastine, a phthalazine derivative, is a potent, second-generation, selective, histamine antagonist used as a first line therapy of mild intermittent.

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Synonyms	1(2h)-phthalazinone,4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1h-azepin; 4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
IUPAC Name	4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one
Molecular Weight	381.9
Molecular Formula	C22H24ClN3O
Canonical SMILES	CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl
InChI	1S/C22H24ClN3O/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16/h2-3,6-11,18H,4-5,12-15H2,1H3
InChIKey	MBUVEWMHONZEQD-UHFFFAOYSA-N
Boiling Point	533.9°C at 760 mmHg
Flash Point	276.7±32.9 °C
Purity	≥98%
Density	1.25 g/cm3
Solubility	Soluble in DMSO
Appearance	white crystal powder
Application	An antihistamine and mast cell stabilizer
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	Store at -20 °C
Complexity	558
Exact Mass	381.160797
Index Of Refraction	1.642
In Vitro	Azelastine can significantly inhibit HNEpC proliferation.
In Vivo	Ameliorated aortic calcification and increased apolipoprotein A expression along with a decline in apolipoprotein B.
PSA	38.13000
Target	Histamine Receptor; SARS-CoV
Vapor Pressure	0.0±1.4 mmHg at 25°C
XLogP3-AA	4.4