Aviptadil-acetate

Category	SARS-CoV
CAS	1444827-29-5
Description	Aviptadil acetate is an analog vasoactive intestinal polypeptide (VIP) with potent vasodilatory effects. It induces pulmonary vasodilation and inhibits vascular SMCs proliferation, platelet aggregation. Aviptadil acetate can be used for the research of pulmonary fibrosis, pulmonary arterial hypertension (PAH) and SARS-CoV-2 caused respiratory failure.

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Product Information

Synonyms	Aviptadil Acetate\|Guinea pig VIP\|Guinea pig VIP octacosapeptide\|VIP, human, porcine, rat VIP (28 amino acids)\|96886-24-7\|AKOS034834067
Molecular Weight	3385.90
Molecular Formula	C147H239N43O42S2
Canonical SMILES	CC(C)CC(C(=O)NC(CC1=CC=CC=C1)C(=O)NC(C(C)O)C(=O)NC(CC(=O)O)C(=O)NC(C(C)O)C(=O)NC(CC2=CC=C(C=C2)O)C(=O)NC(C(C)O)C(=O)NC(CCCNC(=N)N)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(=N)N)C(=O)NC(CCCCN)C(=O)NC(CCC(=O)N)C(=O)NC(CCSC)C(=O)NC(C)C(=O)NC(CCSC)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)NC(CO)C(=O)NC(C(C)C)C(=O)NC(CC(C)C)C(=O)NC(CC(=O)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC(=O)O)NC(=O)C(CO)NC(=O)C(CC4=CNC=N4)N
Purity	≥98% (HPLC)
Solubility	In Vitro: DMSO : 100 mg/mL(29.53 mM;Need ultrasonic) H2O : 100 mg/mL(29.53 mM;Need ultrasonic) In Vivo: 1.Add each solvent one by one:10% DMSO >> 40%PEG300 >> 5%Tween-80 >> 45% saline Solubility: ≥ 2.5 mg/mL (0.74 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: 2.5 mg/mL (0.74 mM); Suspended solution; Need ultrasonic 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.5 mg/mL (0.74 mM); Clear solution
Appearance	White to off-white (Solid)
Storage	Sealed storage, away from moisture and light Powder -80°C, 2 years -20°C, 1 years In solvent -80°C, 6 months -20°C, 1 month (sealed storage, away from moisture and light)
Complexity	7510
Exact Mass	3343.7362760
In Vitro	Aviprodil acetate inhibits basal proliferation of pulmonary artery smooth muscle cells (PASMC) and mobilization of free calcium concentrations within these cells in a dose-dependent manner. Aviprodil acetate has a concentration-dependent inhibitory effect on CSE-induced L2 cell death. Aviprodil acetate (10nm-100 μM) attenuates MMP-9 activity induced by lipopolysaccharide (LPS)-induced rat alveolar macrophages (AM).
In Vivo	Aviprodil acetate (1, 3 and 10 mg/kg; intravenous bolus) injected into the tail vein. CD1 mice are inhaled by nasal inhalation nebulized inhalation. Aviprodil acetate at a dose of 1546 μg / kg / day is well tolerated and does not produce significant changes in any of the parameters evaluated. After a single administration of up to 3920 μg/kg/day, no changes were observed.
Target	SARS-CoV
XLogP3-AA	-13.7