AT-9010 tetrasodium

Category	SARS-CoV
CAS	1621884-18-1
Description	AT-9010 tetrasodium can inhibit SARS-CoV-2 replication.

Quotation Now

Synonyms	AT-9010
IUPAC Name	tetrasodium;[[[(2R,3R,4R,5R)-5-(2-amino-6-oxo-1H-purin-9-yl)-4-fluoro-3-hydroxy-4-methyloxolan-2-yl]methoxy-oxidophosphoryl]oxy-oxidophosphoryl] phosphate
Molecular Weight	627.13
Molecular Formula	C11H13FN5Na4O13P3
Canonical SMILES	CC1(C(C(OC1N2C=NC3=C2N=C(NC3=O)N)COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])O)F.[Na+].[Na+].[Na+].[Na+]
InChI	InChI=1S/C11H17FN5O13P3.4Na/c1-11(12)6(18)4(2-27-32(23,24)30-33(25,26)29-31(20,21)22)28-9(11)17-3-14-5-7(17)15-10(13)16-8(5)19;;;;/h3-4,6,9,18H,2H2,1H3,(H,23,24)(H,25,26)(H2,20,21,22)(H3,13,15,16,19);;;;/q;4*+1/p-4/t4-,6-,9-,11-;;;;/m1..../s1
InChIKey	YSFIWHKJCYGPPP-ZJECJYFYSA-J
Purity	≥98% by HPLC
Solubility	In Vitro: H2O : 100 mg/mL(159.46 mM;Need ultrasonic)
Appearance	White to off-white (Solid)
Storage	-80°C, protect from light, stored under nitrogen
In Vitro	Substantial levels of the active triphosphate metabolite AT-9010 are formed in normal human bronchial and nasal epithelial cells incubated with 10 µM AT-511 (698 µM and 236 µM, respectively), with a half-life of at least 38 hours
Target	SARS-CoV