Aspirin

Category	Virus Protease
CAS	50-78-2
Description	Aspirin is a salicylate and irreversible COX1 and COX2 inhibitor. It can be used for the treatment of fever, rheumatism, nerve, muscle, joint pain, soft tissue inflammation and gout in animals.

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Product Information

Synonyms	Acetylsalicylic acid; 1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
IUPAC Name	2-acetyloxybenzoic acid
Molecular Weight	180.16
Molecular Formula	C9H8O4
Canonical SMILES	CC(=O)OC1=CC=CC=C1C(=O)O
InChI	1S/C9H8O4/c1-6(10)13-8-5-3-2-4-7(8)9(11)12/h2-5H,1H3,(H,11,12)
InChIKey	BSYNRYMUTXBXSQ-UHFFFAOYSA-N
Boiling Point	140°C
Melting Point	134-136°C
Flash Point	131.2±16.7 °C
Purity	99.66%
Density	1.3±0.1 g/cm3
Solubility	Soluble in DMSO (36 mg/mL), Ethanol (36 mg/mL)
Appearance	White Solid
Storage	Store at -20°C
Assay	Unstimulated and interleukin 1 (IL-1) stimulated chondrocytes are used as models to study the effects of drugs on COX-1 and COX-2. Cells are incubated with vehicle or drugs (Asprin); supernatants are removed and the level of prostaglandin E2 (PGE2) in each sample is determined by enzyme immunoassay.
Complexity	212
Exact Mass	487.07428
Index Of Refraction	1.551
In Vivo	Aspirin inhibits NF-κB activation, prevents degradation of its inhibitor, IκB, so that NF-κB remains in the cytoplasm. In transfected T cells, Aspirin also inhibits transcription of NF-κB-dependent Igκ enhancers and HIV-long end repeats. Aspirin inhibits Ser307 phosphorylation and JNK, c-Jun phosphorylation of IRS-1, as well as degradation of IkappaBalpha in TNF-α-treated 3T3-L1 and Hep G2 cells. Aspirin inhibits Akt phosphorylation and inhibits the response of mammalian targets of rapamycin to TNF-α. In 3T3-L1 adipocytes pretreated with TNF-α, Aspirin reduces insulin-induced glucose uptake. In rat neuron primary cultures and hippocampal brain tablets, Aspirin reduces neurotoxicity triggered by the excitatory amino acid glutamate.
PSA	63.60000
Target	COX; Virus Protease; NF-κB; Autophagy; Apoptosis; Mitophagy; Caspase; p38 MAPK
Vapor Pressure	0.0±0.7 mmHg at 25°C
XLogP3-AA	1.2