Arctigenin

Category	Influenza Virus
CAS	7770-78-7
Description	Arctigenin is the aglycone of arctiin and is a lignan found in certain plants of the Asteraceae. It has shown antiviral and anticancer effects in glass. It showed potent in vitro antiviral activities against influenza A virus (A/NWS/33, H1N1) (IFV). It selectively altered the phosphorylation of members of the MAPK superfamily, decreasing phosphorylation of ERK1/2 and activated phosphorylation of p38 significantly in a dose-dependent manner.

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Synonyms	(-)-Arctigenin
Molecular Weight	372.41
Molecular Formula	C21H24O6
Canonical SMILES	COC1=C(C=C(C=C1)CC2COC(=O)C2CC3=CC(=C(C=C3)O)OC)OC
InChI	InChI=1S/C21H24O6/c1-24-18-7-5-13(11-20(18)26-3)8-15-12-27-21(23)16(15)9-14-4-6-17(22)19(10-14)25-2/h4-7,10-11,15-16,22H,8-9,12H2,1-3H3/t15-,16+/m0/s1
InChIKey	NQWVSMVXKMHKTF-JKSUJKDBSA-N
Boiling Point	567.0±45.0 °C at 760 mmHg
Melting Point	100 °C
Flash Point	198.8°C
Purity	>98%
Density	1.227 g/cm³
Solubility	water, 23.08 mg/L @ 25 °C (est)
Appearance	Powder
Application	Antioxidant/anti-inflammatory/antiproliferative/antiviral
Storage	-20°C
Complexity	483
Exact Mass	372.157288
Index Of Refraction	1.576
In Vitro	Arctigenin shows preferential cytotoxicity against the PANC-1 cell line under nutrient-deprived conditions in a concentration- and time-dependent manner. Arctigenin inhibits the survival of various cancer cell lines (ASPC-1, BXPC-3, Alexander, and PSN-1 cells) under nutrient-deprived conditions. Arctigenin completely inhibits Akt phosphorylation stimulated by glucose deprivation in PANC-1 cells. Arctigenin shows potent in vitro antiviral activities (IC50=2.9 μM) against influenza A virus.
PSA	74.22000
Target	MMP; Influenza Virus; Autophagy; Apoptosis
Vapor Pressure	0.0±1.6 mmHg at 25°C
XLogP3-AA	3.6