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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Arbidol hydrochloride
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| Category | Influenza Virus |
| CAS | 131707-23-8 |
| Description | Arbidol is an antiviral agent used for the treatment of influenza infection in Russia and China. It has been used against influenza A and B viruses, and hepatitis C virus (HCV). It has been shown that ARB could inhibit COVID-19 infection through interfering the release of SARS-CoV-2 from intracellular vesicles. It can be used to treat trypanosomiasis in livestock. |
Product Information
| Synonyms | Arbidol HCl; Umifenovir hydrochloride; 6-Bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic Acid Ethyl Ester Hydrochloride |
| IUPAC Name | ethyl 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-(phenylsulfanylmethyl)indole-3-carboxylate;hydrochloride |
| Molecular Weight | 513.88 |
| Molecular Formula | C22H26BrClN2O3S |
| Canonical SMILES | CCOC(=O)C1=C(N(C2=CC(=C(C(=C21)CN(C)C)O)Br)C)CSC3=CC=CC=C3.Cl |
| InChI | InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3;/h6-11,26H,5,12-13H2,1-4H3;1H |
| InChIKey | OMZHXQXQJGCSKN-UHFFFAOYSA-N |
| Boiling Point | 591.8°C at 760 mmHg |
| Melting Point | 133-137°C |
| Purity | >98% |
| Solubility | Soluble in DMSO |
| Appearance | Off-white to Pale Beige Solid |
| Storage | Hygroscopic, Refrigerator, under inert atmosphere |
| Complexity | 546 |
| Exact Mass | 530.06400 |
| In Vitro | Umifenovir hydrochloride exhibits a wide range and potent antiviral activity against a number of viruses including influenza A, B and C viruses, respiratory syncytial virus, adenovirus, parainfluenza type 5 and rhinovirus type 14, avian coronavirus, infectious bronchitis virus and Marek disease virus, hepatitis B virus and hepatitis C virus. |
| In Vivo | Umifenovir (45-180 mg/kg; p.o.; daily for 5 days) suppresses the transcription of Influenza Viruses (IFV) -associated inflammatory cytokines |
| PSA | 89.23000 |
| Target | Influenza Virus |
| Vapor Pressure | 1.34E-14mmHg at 25°C |
