Apricitabine

Category	Human immunodeficiency Virus (HIV)
CAS	160707-69-7
Description	Apricitabine is a highly selective and orally active HIV-1 reverse transcriptase (RT) inhibitor (Ki = 0.08 μM), with Kis of 300, 12 and 112.25 μM against DNA polymerase α, β and γ, respectively. It has been used in trials studying the treatment of HIV Infections.

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Product Information

Synonyms	Apricitabine;160707-69-7;AVX754;AVX-754;SPD754;Apricitabine [INN];BCH 10618;BCH-10618;SPD-754;(-)-dOTC;4-Amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)pyrimidin-2(1H)-one;4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one;K1YX059ML1;SPD -754;BCH-10619;BCH-10652;BCH-10652, (-)-;AVX 754;(-)-2'-Deoxy-3'-oxa-4'-thiocytidine (apricitabine);2(1H)-Pyrimidinone, 4-amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)-;BCH 10618; SPD 754;Apricitabine, (+/-)-;4-Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone;DND9Y3G72C;SPD754;AVX754;UNII-K1YX059ML1;(-)-BCH 10652;2(1H)-Pyrimidinone, 4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-;SPD 754;2(1H)-Pyrimidinone, 4-amino-1-[2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-, (2R-cis)-; 1,3-Oxathiolane, 2(1H)-pyrimidinone deriv.; 4-;Amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]-2(1H)-pyrimidinone; (-)-2'-Deoxy-3'-oxa-4'-thiocytidine; (-)-BCH 10652; AVX 754; Apricitabine;;APRICITABINE [MI];(+/-)dOTC;CHEMBL210651;SCHEMBL1101075;GTPL12677;BCH-270;DTXSID60166974;2(1H)-Pyrimidinone, 4-amino-1-((2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl)-, rel-;DOTC, CIS-(+/-)-;RYMCFYKJDVMSIR-RNFRBKRXSA-N;143338-12-9;BCH10618;BCH10619;BCP07907;MFCD09837753;AKOS022181355;AS-2749;DB12855;2(1H)-Pyrimidinone, 4-amino-1-(2-(hydroxymethyl)-1,3-oxathiolan-4-yl)-, (2R-cis)-;(-)-2'-Deoxy-3'-oxa-4'-thiocytidine;DA-71002;HY-14913;(-)-BCH-10652;(+/-)-2'-Deoxy-3'-oxa-4'-thiocytidine;CS-0003629;NS00069180;2'-DEOXY-3'-OXA-4'-THIOCYTIDINE, CIS-;Q621846;BRD-K55172746-001-01-3;2-(R)-hydroxymethyl-4-(R)-(cytosin-1-yl)-1,3-oxathiolane;(+/-)-cis-1-[2-(Hydroxymethyl)-5-(1,3-oxathiolanyl)]cytosine;
IUPAC Name	4-amino-1-[(2R,4R)-2-(hydroxymethyl)-1,3-oxathiolan-4-yl]pyrimidin-2-one
Molecular Weight	229.26
Molecular Formula	C8H11N3O3S
Canonical SMILES	O=C1N=C(N)C=CN1[C@@H]2S[C@H](CO)OC2
InChI	InChI=1S/C8H11N3O3S/c9-5-1-2-11(8(13)10-5)6-4-14-7(3-12)15-6/h1-2,6-7,12H,3-4H2,(H2,9,10,13)/t6-,7-/m1/s1
InChIKey	RYMCFYKJDVMSIR-RNFRBKRXSA-N
Boiling Point	475.4±55.0°C (Predicted)
Purity	95%
Density	1.73±0.1 g/cm3 (Predicted)
Solubility	Soluble in DMSO
Appearance	Solid Powder
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.