Antiviral-agent-15

Category	SARS-CoV
Description	Antiviral agent 15 (Compound 15f) is a Clofazimine derivative with antiviral effects. Antiviral agent 15 inhibits both rabies virus and pseudo-typed SARS-CoV-2 with EC50 values of 1.45 μM and 14.6 μM, respectively.

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Synonyms	Antiviral agent 15\|HY-144623\|CS-0433077
Molecular Weight	453.51
Molecular Formula	C27H24FN5O
Canonical SMILES	CC(C)N=C1C=C2C(=NC3=CC=CC=C3N2C4=NC=C(C=C4)OC)C=C1NC5=CC(=CC=C5)F
Purity	≥98% (HPLC)
Solubility	In vitro: 10 mM in DMSO
Appearance	Solid powder
Storage	Store at -20°C
Complexity	865
Exact Mass	453.19648857
In Vitro	Antiviral agent 15 (Compound 15f) affects the rabies and SARS-CoV-2 proliferation by targeting G or S protein to block the viral membrane fusion, as well as binding to L protein or nsp13 to inhibit viral biosynthesis, respectively, and thus synergistically exerted antiviral effect.
In Vivo	In Kunming mice, Antiviral agent 15 is given orally in a single-dosing experiment at 0 mg/kg, 200 mg/kg, 400 mg/kg, 600 mg/kg and 800 mg/kg, respectively. The mice are closely monitored for 7 days, and all the surviving mice had glossy hair, fleshy body and good appetiteantiviral agents with dual-target mechanism.
Target	SARS-CoV
XLogP3-AA	5.2