AN-12-H5

Category	Enterovirus (EV)
CAS	1193340-31-6
Description	AN-12-H5, an antienterovirus compound, targets the replication processes of PV and enterovirus 71 (EV71). AN-12-H5 is a bifunctional, enviroxime-like anti-Enterovirus compound that inhibits replication and the early stage of enterovirus 71 infection with EC50 of 0.55 uM; mutations in capsid proteins (G3112A, VP1-Ala224Thr, and G2396A, VP3-Arg227Lys mutations) are resistant to AN-12-H5.

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Synonyms	AN-12-H5\|1193340-31-6\|N-((6AS,8S)-2-(4-(methylthio)phenyl)-6,12-dioxo-5,6,6a,7,8,9,10,12-octahydrobenzo[e]pyrido[1,2-a][1,4]diazepin-8-yl)thiophene-2-sulfonamide\|ACon0_001263\|HY-120900
Molecular Weight	513.645
Molecular Formula	C24H23N3O4S3
Canonical SMILES	CSC1=CC=C(C=C1)C2=CC3=C(C=C2)NC(=O)C4CC(CCN4C3=O)NS(=O)(=O)C5=CC=CS5
Purity	>99.50%
Solubility	DMSO: 100 mg/mL (54.08 mM); H2O: < 0.1 mg/mL (insoluble)
Appearance	Solid powder
Storage	Powder: -20°C: 3 years 4°C: 2 years In solvent: -80°C: 6 months -20°C: 1 month
Complexity	871
Exact Mass	513.08506974
In Vitro	AN-12-H5 shows no inhibitory effect on PI4KB activity and only moderate inhibitory effects on PI 3-kinase activity.
In Vivo	AN-12-H5 shows no inhibitory effect on PI4KB activity and only moderate inhibitory effects on PI 3-kinase activity.
Target	Enterovirus
XLogP3-AA	3.8