Amitivir

Category	Influenza Virus
CAS	111393-84-1
Description	Amitivir is an inosine monophosphate dehydrogenase inhibitor with activity against several influenza A and B viruses and broad antiviral activity against orthomyxoviruses and paramyxoviruses.

Quotation Now

Synonyms	LY 217896; N-(1,3,4-thiadiazol-2-yl)cyanamide; Cyanamide, N-1,3,4-thiadiazol-2-yl-; 1,3,4-Thiadiazole-2-carbamonitrile
IUPAC Name	1,3,4-thiadiazol-2-ylcyanamide
Molecular Weight	126.14
Molecular Formula	C3H2N4S
Canonical SMILES	C1=NN=C(S1)NC#N
InChI	InChI=1S/C3H2N4S/c4-1-5-3-7-6-2-8-3/h2H,(H,5,7)
InChIKey	YUCHAYRHHXJNQK-UHFFFAOYSA-N
Boiling Point	236.3±23.0°C at 760 mmHg
Flash Point	96.7°C
Purity	95%
Density	1.613±0.1 g/cm3
Solubility	Soluble in DMSO
Appearance	Solid Powder
Storage	Store at 2-8°C for short term (days to weeks) or -20°C for long term (months to years)
Complexity	116
Exact Mass	126.00000
Index Of Refraction	1.703
In Vitro	The mean 50% inhibitory concentration of Amitivir inhibits six strains of type A influenzaranged from 0.37 to 1.19 μg/ml. The mean 50% inhibitory concentration of Amitivir inhibits four strains of influenza B virus ranged from 0.75 to 1.54 μg/ml.
In Vivo	Amitivir (LY 217896) (9 mg/m2 of body surface area per day) administered in the diet, in the drinking water, by oral gavage, by intraperitoneal injection, or by aerosolization was well tolerated and protected CD-1 mice infected with a lethal dose of influenza A or B virus.
PSA	93.07000
Target	Influenza Virus
Vapor Pressure	0.0477mmHg at 25°C
XLogP3-AA	0.7