Amantadine Hydrochloride

Category	Influenza Virus
CAS	665-66-7
Description	Amantadine Hydrochloride is a NMDA-receptor antagonist acts as an antiviral and an antiparkinsonian drug.

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Synonyms	1-Adamantanamine hydrochloride; adamantan-1-amine;hydrochloride
IUPAC Name	adamantan-1-amine;hydrochloride
Molecular Weight	187.71
Molecular Formula	C10H18ClN
Canonical SMILES	C1C2CC3CC1CC(C2)(C3)N.Cl
InChI	1S/C10H17N.ClH/c11-10-4-7-1-8(5-10)3-9(2-7)6-10;/h7-9H,1-6,11H2;1H
InChIKey	WOLHOYHSEKDWQH-UHFFFAOYSA-N
Melting Point	360 °C
Purity	95%
Density	1.067g/cm3
Solubility	Soluble in DMSO
Appearance	White Solid
Application	Dopaminergic agent. Antiviral.
Shelf Life	As supplied, 2 years from the QC date provided on the Certificate of Analysis, when stored properly
Storage	Store at -20 °C
Complexity	144
Exact Mass	187.112778
In Vitro	Amantadine hydrochloride (0-500 µM, 26 h) inhibits SARS-CoV-2 replication, with IC50 concentrations between 83 and 119 µM. Amantadine hydrochloride (0-100 µg/mL, 24-72 h) markedly inhibits the proliferation of HepG2 and SMMC‑7721 cells. Amantadine hydrochloride (0-75 µg/mL, 48 h) arrests the cell cycle at the G0/G1 phase and induces Apoptosis. Amantadine hydrochloride (0-75 µg/mL, 48 h) reduces the levels of the cell cycle‑related genes and proteins (cyclin D1, cyclin E and CDK2), reduces Bcl-2 and increases the Bax protein and mRNA levels.
In Vivo	Amantadine hydrochloride (25 mg/kg, IP, once daily for 3 days) inhibits surgery induced neuroinflammation and learning and memory impairment.
Target	Influenza Virus; Orthopoxvirus; SARS-CoV; Apoptosis; Bcl-2 Family; CDK