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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
ALS-8176 (active form)
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| Category | Respiratory syncytial Virus (RSV) |
| CAS | 1445379-92-9 |
| Description | ALS-8176 (active form), a 4'-substituted cytidine analogue, is a potent, selective RSV polymerase inhibitor. It has an EC50 of 0.15 μM in the RSV replicon assay and an IC50= 0.02 μM due to its corresponding 5'-triphosphate in the RSV polymerase assay. |
Product Information
| Synonyms | 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-oneALS-8176 (active form); ALS-8112; ALS8112; ALS 8112.UNII-7795987MKM7795987MKMCHEMBL3417243SCHEMBL15070479CS-5472; HY-12983; CS 5472; HY 12983; CS5472; HY129834'-Chloromethyl-2'-deoxy-2'-fluorocytidineCytidine, |
| IUPAC Name | 4-amino-1-[(2R,3R,4R,5R)-5-(chloromethyl)-3-fluoro-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one |
| Molecular Weight | 293.68 |
| Molecular Formula | C10H13ClFN3O4 |
| Canonical SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)(CO)CCl)O)F |
| InChI | 1S/C10H13ClFN3O4/c11-3-10(4-16)7(17)6(12)8(19-10)15-2-1-5(13)14-9(15)18/h1-2,6-8,16-17H,3-4H2,(H2,13,14,18)/t6-,7+,8-,10-/m1/s1 |
| InChIKey | AWSRKKBIPSQHOJ-IBCQBUCCSA-N |
| Boiling Point | 532.8±60.0 °C | Condition: Press: 760 Torr |
| Flash Point | 276.0±32.9 °C |
| Purity | 99.67% |
| Density | 1.78±0.1 g/cm3 |
| Solubility | Soluble to > 47 mg/mL in DMSO |
| Appearance | Solid powder |
| Shelf Life | 2 years |
| Storage | Store in a cool and dry place and at 0 - 4°C for short term (days to weeks) or -58°C for long term (months to years). |
| Complexity | 447 |
| Exact Mass | 293.057861 |
| Index Of Refraction | 1.668 |
| In Vitro | The 5'-triphosphate form of ALS-8112 is the active form of the drug and selectively inhibits RSV polymerase through chain termination of RNA synthesis. ALS-008112 enters various types of epithelial cells in the respiratory tract and is subsequently phosphorylated to form an intracellular nucleoside triphosphate. It is a pan-strain inhibitor of RSV replication in vitro. The RNA transcription activity of the RSV-RNP complex is dose-proportionally inhibited by ALS-8112-TP with an IC50 of 0.020 ± 0.008 μM. |
| Target | IC50: 0.02 μM (RSV) |
| Vapor Pressure | 0.0±3.2 mmHg at 25°C |
| XLogP3-AA | -1.2 |
