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Antiviral API
- Arenavirus
- Cytomegalovirus (CMV)
- Dengue virus
- Endogenous Metabolite
- Enterovirus (EV)
- Epstein-Barr virus (EBV)
- Filovirus
- Flavivirus
- HCV Protease
- Hepatitis B Virus (HBV)
- Hepatitis C Virus (HCV)
- Herpes simplex Virus (HSV)
- HIF/HIF Prolyl-Hydroxylase
- HIV Integrase
- HIV Protease
- Human immunodeficiency Virus (HIV)
- Human papillomavirus (HPV)
- Influenza Virus
- Nipah virus
- Orthopoxvirus
- Others
- Rabies virus (RABV)
- Respiratory syncytial Virus (RSV)
- Reverse Transcriptases (RTs)
- SARS-CoV
- Tobacco mosaic virus (TMV)
- Vesicular stomatitis virus (VSV)
- Virus Protease
- West Nile virus
- Antiviral intermediates
Aloperine
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| Category | Human immunodeficiency Virus (HIV) |
| CAS | 56293-29-9 |
| Description | Aloperine is an isolated alkaloid in sophora plants such as Sophora alopecuroides L, and exhibits anti-inflammatory, antibacterial, antiviral, and anti-tumor properties. Aloperine induces apoptosis and autophagy in HL-60 cells. |
Product Information
| Synonyms | (6R,6aR,13S,13aS)-1,3,4,6,6a,7,8,9,10,12,13,13a-Dodecahydro-2H-6,13-methanodipyrido[1,2-a:3',2'-e]azocine; (7-alpha,9-alpha)-9-De-2-piperidinyl-16,17-didehydro-ormosanine; Ormosanine, 16,17-didehydro-9-de-2-piperidinyl-, (7-alpha,9-alpha)-; Allopterin; 6,13-Methano-2H-dipyrido[1,2-a:3',2'-e]azocine,1,3,4,6,6a,7,8,9,10,12,13,13a-dodecahydro-,[6R-(6α,6aβ,13α,13aα)]- |
| IUPAC Name | (1R,2S,9R,10R)-3,15-diazatetracyclo[7.7.1.02,7.010,15]heptadec-7-ene |
| Molecular Weight | 232.36 |
| Molecular Formula | C15H24N2 |
| Canonical SMILES | C1CCN2CC3CC(C2C1)C=C4C3NCCC4 |
| InChI | InChI=1S/C15H24N2/c1-2-7-17-10-13-9-12(14(17)5-1)8-11-4-3-6-16-15(11)13/h8,12-16H,1-7,9-10H2/t12-,13+,14+,15+/m0/s1 |
| InChIKey | SKOLRLSBMUGVOY-GBJTYRQASA-N |
| Boiling Point | 367.7±37.0 °C at 760 mmHg |
| Melting Point | 69 - 71°C |
| Flash Point | 155.8±17.5 °C |
| Purity | >98% |
| Density | 1.1±0.1 g/cm3 |
| Solubility | In Vitro: DMSO : ≥ 100 mg/mL(82.19 mM) to 60°C) H2O : < 0.1 mg/mL In Vivo: 1.Add each solvent one by one:10% DMSO >> 40% PEG300 >> 5% Tween-80 >> 45% saline Solubility: ≥ 2.08 mg/mL (8.95 mM); Clear solution 2.Add each solvent one by one:10% DMSO >> 90% (20%SBE-β-CDin saline) Solubility: ≥2.08 mg/mL (8.95 mM); Clear solution 3.Add each solvent one by one:10% DMSO >> 90%corn oil Solubility: ≥ 2.08 mg/mL (8.95 mM); Clear solution |
| Appearance | White to off-white (Solid) |
| Application | Anti-inflammatory, antibacterial, antiviral, and antitumor |
| Storage | Powder: -20°C 3 years In solvent: -80°C 6 months |
| Animal Admin | Female BALB/c mice with DNFB-induced allergic contact dermatitis. |
| Complexity | 336 |
| Exact Mass | 232.193954 |
| Index Of Refraction | 1.583 |
| In Vitro | Aloperine (1-20 μM; 24 hours) gives growth-inhibitory IC50 values in cancer cells ranges from 0.04 to 1.36 mM. Aloperine (1-20 μM; 24 hours) induces Apoptosis and decreases bcl-2 expression in HL-60 cells. |
| In Vivo | In contrast to the effect on leukemia cells, up to 1 mM Aloperine does not significantly reduce the viability of normal PBMNCs at 72 hours. 20 μM Aloperine treatment for 48 h with pronounced dose-dependent induction of Apoptosis and Autophagy in HL-60 cells. Aloperine acts on HL-60 cells and the strongest cytotoxicity is observed at 72 h with an inhibition rate of 94.1%. |
| PSA | 15.27000 |
| Target | Apoptosis; Autophagy; Filovirus; HIV |
| Vapor Pressure | 0.0±0.8 mmHg at 25°C |
| XLogP3-AA | 1.6 |
