AL-611

Category	HCV Protease
CAS	2481279-61-0
Description	AL-611 is a small molecule that has been investigated for its potential antiviral properties, specifically targeting RNA-dependent RNA polymerase (RdRP) enzymes. RdRP enzymes are crucial for the replication of RNA viruses, and inhibitors like AL-611 aim to disrupt this process, potentially offering therapeutic benefits for treating viral infections. AL-611 is an HCV NS5B polymerase inhibitor with an EC50 of 5 nM.

Quotation Now

Synonyms	Isopropyl ((S)-(((2S,3S,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-2,4-difluoro-3-hydroxy-4-methyltetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate; Isopropyl (2S)-2-{[{[(2S,3S,4R,5R)-5-(2-amino-6-ethoxy-9H-purin-9-yl)-2,4-difluoro-3-hydroxy-4-methyltetrahydro-2-furanyl]methoxy}-(S)-(phenoxy)phosphoryl]amino}propanoate; N-[(2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-4'-C-fluoro-2'-methyl-(S)-P-phenyl-5'-guanylyl]-L-alanine 1-methylethyl ester; Isopropyl N-[(2'R)-2'-Deoxy-6-O-ethyl-2'-fluoro-4'-C-fluoro-2'-methyl-(S)-P-phenyl-5'-guanylyl]-L-alanine
IUPAC Name	propan-2-yl (2S)-2-[[[(2S,3S,4R,5R)-5-(2-amino-6-ethoxypurin-9-yl)-2,4-difluoro-3-hydroxy-4-methyloxolan-2-yl]-(S)-methoxy-phenoxyphosphoryl]amino]propanoate
Molecular Weight	614.54
Molecular Formula	C25H33F2N6O8P
Canonical SMILES	O=C(OC(C)C)C(NP(=O)(OC=1C=CC=CC1)OCC2(F)OC(N3C=NC=4C(=NC(=NC43)N)OCC)C(F)(C)C2O)C
InChI	InChI=1S/C25H33F2N6O8P/c1-6-37-19-17-18(30-23(28)31-19)33(13-29-17)22-24(5,26)21(35)25(27,40-22)12-38-42(36,41-16-10-8-7-9-11-16)32-15(4)20(34)39-14(2)3/h7-11,13-15,21-22,35H,6,12H2,1-5H3,(H,32,36)(H2,28,30,31)/t15-,21-,22+,24+,25+,42-/m0/s1
InChIKey	ZPUNZSJZZGWNSN-YFSNHYMXSA-N
Boiling Point	758.9±70.0 °C at 760 mmHg
Purity	≥95%
Density	1.52±0.1 g/cm3
Storage	Store at -20 °C
Target	HCV Protease